Evidence map›Paper›PMID 34681887›Full record

ArticleInternational journal of molecular sciences2021

In Silico and In Vivo Analysis of Amino Acid Substitutions That Cause Laminopathies.

Benjamin E Hinz, Sydney G Walker, Austin Xiong, Rose A Gogal, Michael J Schnieders, Lori L Wallrath

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. An Unbiased Drug Screen in a Drosophila Model ofInternational journal of molecular sciences · 2026
    Article
  2. Cells · 2025
    Review
  3. Article
  4. A genetic variant inScience advances · 2025
    Article
  5. Article
  6. The Influence of a Genetic Variant inInternational journal of molecular sciences · 2024
    Article
  7. Science advances · 2023
    Article
  8. Nuclear damage inMolecular biology of the cell · 2023
    Article
  9. Article
  10. Effects of mutant lamins on nucleo-cytoskeletal coupling inFrontiers in cell and developmental biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Benjamin E HinzDepartment of Biochemistry, University of Iowa, Iowa City, IA 52242, USA.
Sydney G WalkerDepartment of Biochemistry, University of Iowa, Iowa City, IA 52242, USA.
Austin XiongDepartment of Biochemistry, University of Iowa, Iowa City, IA 52242, USA.
Rose A GogalDepartment of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA.
Michael J SchniedersDepartment of Biochemistry, University of Iowa, Iowa City, IA 52242, USA.
Lori L WallrathDepartment of Biochemistry, University of Iowa, Iowa City, IA 52242, USA.
University of Iowa · US

Funding

Smad signaling in skeletal muscle laminopathiesR21AR075193 · NIAMS · UNIVERSITY OF IOWA · PI WALLRATH, LORI L · 2020 to 2021
$369k
NIAMS NIH HHS R21 AR075193NIAMS NIH HHS R21AR075193
6 · The paper itself

Abstract

Mutations in the

Indexed as

Computer SimulationMutationAmino Acid SubstitutionAnimalsChild, PreschoolDrosophila melanogasterFemaleHumansInfantLaminopathiesLamin Type AMaleMuscle, SkeletalMuscular DystrophiesNuclear EnvelopePhenotypelamin CLamin Type ALMNA protein, humancongenital muscular dystrophyEmery–Dreifuss muscular dystrophyintermediate filamentslaminopathylaminsnuclear envelope

Identifiers

PMID34681887
PMCPMC8536974
OpenAlexW3207361436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.