Evidence map›Paper›PMID 34681873›Full record

ArticleInternational journal of molecular sciences2021

Modifications in Gene Expression in the Process of Osteoblastic Differentiation of Multipotent Bone Marrow-Derived Human Mesenchymal Stem Cells Induced by a Novel Osteoinductive Porous Medical-Grade 3D-Printed Poly(ε-caprolactone)/β-tricalcium Phosphate Composite.

Ivan López-González, Camilo Zamora-Ledezma, María Isabel Sanchez-Lorencio, Elena Tristante Barrenechea, José Antonio Gabaldón-Hernández, Luis Meseguer-Olmo

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Rapid mineralization of hydrothermally induced TiOJournal of materials science. Materials in medicine · 2026
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  7. Fabrication and Characterization of a Porous TiOACS biomaterials science & engineering · 2025
    Article
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  9. Article
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  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ivan López-GonzálezTissue Regeneration and Repair Group, Orthobiology, Biomaterials and Tissue Engineering, Campus de los Jerónimos 135, UCAM-Universidad Católica de Murcia, Guadalupe, 30107 Murcia, Spain.ORCID 0000-0002-9147-6770
Camilo Zamora-LedezmaTissue Regeneration and Repair Group, Orthobiology, Biomaterials and Tissue Engineering, Campus de los Jerónimos 135, UCAM-Universidad Católica de Murcia, Guadalupe, 30107 Murcia, Spain.ORCID 0000-0002-8704-1539
María Isabel Sanchez-LorencioBiomedical Research Institute of Murcia (IMIB-Arrixaca-UMU), University Clinical Hospital "Virgen de la Arrixaca", University of Murcia, El Palmar, 30120 Murcia, Spain.
Elena Tristante BarrenecheaPlataforma Sala Blanca, IMIB-Arrixaca, Carretera Madrid-Cartagena S/N, El Palmar, 30120 Murcia, Spain.
José Antonio Gabaldón-HernándezMolecular Recognition and Encapsulation Research Group (REM), Health Sciences Department, Campus de los Jerónimos 135, UCAM-Universidad Católica de Murcia, Guadalupe, 30107 Murcia, Spain.ORCID 0000-0002-6649-2920
Luis Meseguer-OlmoTissue Regeneration and Repair Group, Orthobiology, Biomaterials and Tissue Engineering, Campus de los Jerónimos 135, UCAM-Universidad Católica de Murcia, Guadalupe, 30107 Murcia, Spain.ORCID 0000-0003-3858-8148
Universidad Católica de Murcia · ESInstituto Murciano de Investigación Biosanitaria · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, we evaluated the influence of a novel hybrid 3D-printed porous composite scaffold based on poly(ε-caprolactone) (PCL) and β-tricalcium phosphate (β-TCP) microparticles in the process of adhesion, proliferation, and osteoblastic differentiation of multipotent adult human bone marrow mesenchymal stem cells (

Indexed as

Alkaline PhosphataseCalcium PhosphatesCell AdhesionCell DifferentiationCell ProliferationCells, CulturedGene Expression RegulationHumansMesenchymal Stem CellsOsteoblastsOsteogenesisPolyestersPorosityPrinting, Three-DimensionalTissue ScaffoldsX-Ray MicrotomographyAlkaline Phosphatasebeta-tricalcium phosphateCalcium PhosphatespolycaprolactonePolyesters3D printingcell therapiescomposite filamentflow cytometrymesenchymal stem cellsmicroparticlespoly(ε-caprolactone)qRT-PCRtissue engineeringβ-tricalcium phosphate

Identifiers

PMID34681873
PMCPMC8537621
OpenAlexW3205442214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.