Evidence map›Paper›PMID 34681802›Full record

ArticleInternational journal of molecular sciences2021

Potential Novel Thioether-Amide or Guanidine-Linker Class of SARS-CoV-2 Virus RNA-Dependent RNA Polymerase Inhibitors Identified by High-Throughput Virtual Screening Coupled to Free-Energy Calculations.

Marko Jukič, Dušanka Janežič, Urban Bren

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Autochthonous Peruvian Natural Plants as Potential SARS-CoV-2 MPharmaceuticals (Basel, Switzerland) · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marko JukičLaboratory of Physical Chemistry and Chemical Thermodynamics, Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova 17, SI-2000 Maribor, Slovenia.ORCID 0000-0001-6083-5024
Dušanka JanežičFaculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska, Glagoljaška 8, SI-6000 Koper, Slovenia.ORCID 0000-0003-4067-0116
Urban BrenLaboratory of Physical Chemistry and Chemical Thermodynamics, Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova 17, SI-2000 Maribor, Slovenia.

Funding

Ministry of Education, Science and Sport HPC-RIVRMinistry of Education, Science and Sport OP20.04342Slovenian Research Agency J1-1715Slovenian Research Agency J1-2471Slovenian Research Agency J1-9186Slovenian Research Agency P2-0046
6 · The paper itself

Abstract

SARS-CoV-2, or severe acute respiratory syndrome coronavirus 2, represents a new pathogen from the family of

Indexed as

AmidesAntiviral AgentsBinding SitesCatalytic DomainCOVID-19COVID-19 Drug TreatmentDatabases, ChemicalDrug DesignEnzyme InhibitorsGuanidineHumansMolecular Docking SimulationMolecular Dynamics SimulationRNA-Dependent RNA PolymeraseSARS-CoV-2Structure-Activity RelationshipAmidesAntiviral AgentsEnzyme InhibitorsGuanidineRNA-Dependent RNA PolymeraseSulfidesViral Proteinsbinding site identificationCOVID-19ensemble dockingfree-energy calculationsin silico drug designmolecular dynamicsnon-covalent inhibitorsRNA-dependent RNA polymeraseSARS-CoV-2 virusvirtual screening

Identifiers

PMID34681802
PMCPMC8540652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.