Evidence map›Paper›PMID 34681766›Full record

ArticleInternational journal of molecular sciences2021

The Expression and Localisation of G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels Is Differentially Altered in the Hippocampus of Two Mouse Models of Alzheimer's Disease.

Rocío Alfaro-Ruiz, Alejandro Martín-Belmonte, Carolina Aguado, Félix Hernández, Ana Esther Moreno-Martínez, Jesús Ávila, Rafael Luján

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. G protein-gated inwardly rectifying KHistology and histopathology · 2025
    Review
  4. Article
  5. Review
  6. Systematic characterization of a non-transgenic AβBiology of sex differences · 2023
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Nanoscale alterations in GABAAlzheimer's research & therapy · 2022
    Article
  13. Neuronal G protein-gated KAmerican journal of physiology. Cell physiology · 2022
    Review
  14. AsKC11, a Kunitz Peptide fromMarine drugs · 2022
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rocío Alfaro-RuizSynaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario, C/Almansa 14, 02008 Albacete, Spain.
Alejandro Martín-BelmonteSynaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario, C/Almansa 14, 02008 Albacete, Spain.ORCID 0000-0001-5006-2523
Carolina AguadoSynaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario, C/Almansa 14, 02008 Albacete, Spain.ORCID 0000-0003-0265-8124
Félix HernándezCentro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas, ISCIII, 28049 Madrid, Spain.ORCID 0000-0001-8753-8249
Ana Esther Moreno-MartínezSynaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario, C/Almansa 14, 02008 Albacete, Spain.
Jesús ÁvilaCentro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas, ISCIII, 28049 Madrid, Spain.ORCID 0000-0002-6288-0571
Rafael LujánSynaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario, C/Almansa 14, 02008 Albacete, Spain.ORCID 0000-0003-2001-9545
University of Castilla-La Mancha · ESInstituto de Salud Carlos III · ES

Funding

Ministry of Economy, Industry and Competitiveness RTI2018-095812-B-I00Regional Government of Castile-La Mancha SBPLY/17/180501/000229
6 · The paper itself

Abstract

G protein-gated inwardly rectifying K

Indexed as

Alzheimer DiseaseAnimalsCA1 Region, HippocampalCell MembraneDisease Models, AnimalG Protein-Coupled Inwardly-Rectifying Potassium ChannelsHippocampusMaleMice, TransgenicNeuronal PlasticityPresenilin-1tau ProteinsG Protein-Coupled Inwardly-Rectifying Potassium ChannelsKcnj6 protein, mouseMAPT protein, humanPresenilin-1PSEN1 protein, humantau ProteinsAD mouse modelAlzheimer´s diseaseAPP/PS1electron microscopyGIRK channelshippocampushistoblotimmunohistochemistryP301S

Identifiers

PMID34681766
PMCPMC8541655
OpenAlexW3206638307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.