ReviewInternational journal of molecular sciences2021
Interleukin-15 in Outcomes of Pregnancy.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Interplay between systemic immune-metabolic signatures and endometrial immune profiles in women with recurrent pregnancy loss.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Identification of Maternal Serum Longitudinal Signatures Through Profiling of 96 Cytokines.Life (Basel, Switzerland) · 2026Article
- Immune mechanisms in the pathogenesis of endometriosis: a comprehensive analysis of the role of NK cells, cytokines, and extracellular vesicles/exosomes.Frontiers in immunology · 2026Review
- JEG-3 Trophoblast Cells Influence ILC-like Transformation of NK Cells In Vitro.International journal of molecular sciences · 2025Article
- Function of immune cells and effector molecules of the innate immune system in the establishment and maintenance of pregnancy in mammals - A review.Animal bioscience · 2024Article
- Distinct maternofetal immune signatures delineate preterm birth onset following urinary tract infection.bioRxiv : the preprint server for biology · 2024Article
- Fetal brain response to maternal inflammation requires microglia.Development (Cambridge, England) · 2024Article
- High-throughput mRNA-seq atlas of human placenta shows vast transcriptome remodeling from first to third trimester†.Biology of reproduction · 2024Article
- Interferon-epsilon is a novel regulator of NK cell responses in the uterus.EMBO molecular medicine · 2024Article
- Uterine macrophages and NK cells exhibit population and gene-level changes after implantation but maintain pro-invasive properties.Frontiers in immunology · 2024Article
- Genome-wide neonatal epigenetic changes associated with maternal exposure to the COVID-19 pandemic.BMC medical genomics · 2023Observational
- Immune Cell Functionality during Decidualization and Potential Clinical Application.Life (Basel, Switzerland) · 2023Review
- Placental Related Disorders of Pregnancy.International journal of molecular sciences · 2022Article
- Killer Timing: The Temporal Uterine Natural Killer Cell Differentiation Pathway and Implications for Female Reproductive Health.Frontiers in endocrinology · 2022Review
- Uterine Natural Killer Cells: A Rising Star in Human Pregnancy Regulation.Frontiers in immunology · 2022Review
- Mechanisms of Decidual Dysfunction and Infertility in Endometriosis: Roles of Prostaglandins and SASP.Reproductive medicine and biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Interleukin-15 (IL-15) is a pleiotropic cytokine that classically acts to support the development, maintenance, and function of killer lymphocytes. IL-15 is abundant in the uterus prior to and during pregnancy, but it is subject to tight spatial and temporal regulation. Both mouse models and human studies suggest that homeostasis of IL-15 is essential for healthy pregnancy. Dysregulation of IL-15 is associated with adverse outcomes of pregnancy. Herein, we review producers of IL-15 and responders to IL-15, including non-traditional responders in the maternal uterus and fetal placenta. We also review regulation of IL-15 at the maternal-fetal interface and propose mechanisms of action of IL-15 to facilitate additional study of this critical cytokine in the context of pregnancy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.