SynthesisInternational journal of molecular sciences2021
The Role of the Noradrenergic System in Eating Disorders: A Systematic Review.
Synthesis in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Effects of bariatric surgery and dietary interventions for obesity on brain neurotransmitter systems and metabolism: A systematic review of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023Pooled it
- The Follow-Up of Eating Disorders from Adolescence to Early Adulthood: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Exploring the Impact of Extended Amino Acid Supplementation on Body Composition and Psychopathology in Patients with Eating Disorders Undergoing Psycho-Nutritional RehabilitationEndocrine, metabolic & immune disorders drug targets · 2026Article
- Obesity-related alterations of intrinsic functional architecture: a resting-state fMRI study based on the human connectome project.Frontiers in nutrition · 2025Article
- How feasible is nutrition intervention research in eating disorders? Lessons learnt from a pilot parallel randomised controlled trial of tyrosine supplementation in adolescents with anorexia nervosa.Journal of eating disorders · 2024Article
- Stress integration by an ascending adrenergic-melanocortin circuit.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- A neural pathway integrating stress and feeding.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Pharmacological strategies for appetite modulation in eating disorders: a narrative review.Consortium psychiatricum · 2023Review
- Food and Development: Children and Adolescents with Neurodevelopmental and Comorbid Eating Disorders-A Case Series.Behavioral sciences (Basel, Switzerland) · 2023Article
- Premenarchal anorexia nervosa: clinical features, psychopharmacological interventions, and rehospitalization analysis in a 1-year follow-up, controlled study.European journal of pediatrics · 2023Observational
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- Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Noradrenaline (NE) is a catecholamine acting as both a neurotransmitter and a hormone, with relevant effects in modulating feeding behavior and satiety. Several studies have assessed the relationship between the noradrenergic system and Eating Disorders (EDs). This systematic review aims to report the existing literature on the role of the noradrenergic system in the development and treatment of EDs. A total of 35 studies were included. Preclinical studies demonstrated an involvement of the noradrenergic pathways in binge-like behaviors. Genetic studies on polymorphisms in genes coding for NE transporters and regulating enzymes have shown conflicting evidence. Clinical studies have reported non-unanimous evidence for the existence of absolute alterations in plasma NE values in patients with Anorexia Nervosa (AN) and Bulimia Nervosa (BN). Pharmacological studies have documented the efficacy of noradrenaline-modulating therapies in the treatment of BN and Binge Eating Disorder (BED). Insufficient evidence was found concerning the noradrenergic-mediated genetics of BED and BN, and psychopharmacological treatments targeting the noradrenergic system in AN. According to these data, further studies are required to expand the existing knowledge on the noradrenergic system as a potential target for treatments of EDs.
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