Evidence map›Paper›PMID 34681725›Full record

ArticleInternational journal of molecular sciences2021

Copper-Containing Nanoparticles and Organic Complexes: Metal Reduction Triggers Rapid Cell Death via Oxidative Burst.

Sergey A Tsymbal, Anna A Moiseeva, Nikol A Agadzhanian, Svetlana S Efimova, Alina A Markova, Dmitry A Guk, Olga O Krasnovskaya, Victoria M Alpatova, Andrei V Zaitsev, Anna V Shibaeva and 6 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  14. Study on Computer Screening and Drug Properties of Herbs Intervening in Copper Death.Computational and mathematical methods in medicine · 2023
    Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Sergey A TsymbalInternational Institute of Solution Chemistry of Advanced Materials and Technologies, ITMO University, 197101 Saint Petersburg, Russia.ORCID 0000-0003-2230-6767
Anna A MoiseevaDepartment of Chemistry, Moscow State University, 119991 Moscow, Russia.
Nikol A AgadzhanianInternational Institute of Solution Chemistry of Advanced Materials and Technologies, ITMO University, 197101 Saint Petersburg, Russia.
Svetlana S EfimovaInstitute of Cytology, Russian Academy of Sciences, 194064 Saint Petersburg, Russia.ORCID 0000-0002-2429-2007
Alina A MarkovaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334 Moscow, Russia.
Dmitry A GukDepartment of Chemistry, Moscow State University, 119991 Moscow, Russia.ORCID 0000-0002-5674-8654
Olga O KrasnovskayaDepartment of Chemistry, Moscow State University, 119991 Moscow, Russia.ORCID 0000-0002-4948-2747
Victoria M AlpatovaA.N.Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119334 Moscow, Russia.ORCID 0000-0002-5014-9781
Andrei V ZaitsevA.N.Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119334 Moscow, Russia.ORCID 0000-0001-6448-2561
Anna V ShibaevaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334 Moscow, Russia.ORCID 0000-0002-5904-4521
Victor V TatarskiyInstitute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.
Marina S DukhinovaInternational Institute of Solution Chemistry of Advanced Materials and Technologies, ITMO University, 197101 Saint Petersburg, Russia.
Valentina A Ol'shevskayaA.N.Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119334 Moscow, Russia.
Olga S OstroumovaInstitute of Cytology, Russian Academy of Sciences, 194064 Saint Petersburg, Russia.
Elena K BeloglazkinaDepartment of Chemistry, Moscow State University, 119991 Moscow, Russia.
Alexander A ShtilDepartment of Chemistry, Moscow State University, 119991 Moscow, Russia.
Lomonosov Moscow State University · RUA. N. Nesmeyanov Institute of Organoelement Compounds · RUITMO University · RUInstitute of Cytology · RUInstitute of Biochemical Physics NM Emanuel · RUInstitute of Gene Biology · RU

Funding

Russian Foundation for Basic Research Project 19-29-08007
6 · The paper itself

Abstract

Copper-containing agents are promising antitumor pharmaceuticals due to the ability of the metal ion to react with biomolecules. In the current study, we demonstrate that inorganic Cu

Indexed as

AcetylcysteineApoptosisCell Cycle CheckpointsCell Line, TumorCoordination ComplexesCopperDrug Resistance, NeoplasmDrug Screening Assays, AntitumorHumansLiposomesMembrane Potential, MitochondrialMetal NanoparticlesOxidation-ReductionOxidative StressSuperoxidesAcetylcysteineCoordination ComplexesCopperLiposomesSuperoxidescell deathcopperdrug resistancereactive oxygen speciesredox potentialtumor cells

Identifiers

PMID34681725
PMCPMC8539714
OpenAlexW3205108565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.