Direct and Base Excision Repair-Mediated Regulation of a GC-Rich

Nadine Müller, Eveliina Ponkkonen, Thomas Carell, Andriy Khobta

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 50% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Requirement of transcription-coupled nucleotide excision repair for the removal of a specific type of oxidatively induced DNA damage.Nucleic acids research · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nadine MüllerInstitute of Toxicology, University Medical Center Mainz, 55131 Mainz, Germany.

Eveliina PonkkonenDepartment of Chemistry and Biochemistry, Ludwig-Maximilians University Munich, 81377 Munich, Germany.

Thomas CarellDepartment of Chemistry and Biochemistry, Ludwig-Maximilians University Munich, 81377 Munich, Germany.

Andriy KhobtaInstitute of Toxicology, University Medical Center Mainz, 55131 Mainz, Germany.ORCID 0000-0001-9165-3557

Johannes Gutenberg University Mainz · DELudwig-Maximilians-Universität München · DE

Funding

Deutsche Forschungsgemeinschaft KH263/2-2Deutsche Forschungsgemeinschaft KH263/5-1Deutsche Forschungsgemeinschaft project-ID 321812289 - GRK 2338Deutsche Forschungsgemeinschaft project-ID 393547839 - SFB 1361European Union's Horizon 2020 research and innovation programme Marie Sklodowska-Curie grant agreement No. 765266

6 · The paper itself

Abstract

Stepwise oxidation of the epigenetic mark 5-methylcytosine and base excision repair (BER) of the resulting 5-formylcytosine (5-fC) and 5-carboxycytosine (5-caC) may provide a mechanism for reactivation of epigenetically silenced genes; however, the functions of 5-fC and 5-caC at defined gene elements are scarcely explored. We analyzed the expression of reporter constructs containing either 2'-deoxy-(5-fC/5-caC) or their BER-resistant 2'-fluorinated analogs, asymmetrically incorporated into CG-dinucleotide of the GC box

Indexed as

CpG IslandsDNA DamageDNA RepairPromoter Regions, GeneticCytosineDeoxyribonuclease (Pyrimidine Dimer)DNADNA DemethylationDNA MethylationEpigenesis, GeneticHeLa CellsHumansThymine DNA Glycosylase5-carboxycytosine5-formylcytosineCytosineDeoxyribonuclease (Pyrimidine Dimer)DNANTHL1 protein, humanThymine DNA Glycosylase5-carboxycytosine5-formylcytosinebase excision repair (BER)DNA demethylationepigenetic marksgene regulationthymine DNA glycosylase (TDG)

Identifiers

PMID34681690

DOI10.3390/ijms222011025

PMCPMC8539351

OpenAlexW3206719263

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.