Evidence map›Paper›PMID 34681679›Full record

ArticleInternational journal of molecular sciences2021

The M2a Macrophage Phenotype Accompanies Pulmonary Granuloma Resolution in

David Ogburn, Sophia Bhalla, Nan Leffler, Arjun Mohan, Anagha Malur, Achut G Malur, Matthew McPeek, Barbara P Barna, Mary Jane Thomassen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Overview of multi-omics approaches for pulmonary sarcoidosis.EC pulmonology and respiratory medicine · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

David OgburnDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Brody School of Medicine Sciences Building, East Carolina University, Moye Boulevard, Greenville, NC 27834, USA.
Sophia BhallaDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Brody School of Medicine Sciences Building, East Carolina University, Moye Boulevard, Greenville, NC 27834, USA.
Nan LefflerDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Brody School of Medicine Sciences Building, East Carolina University, Moye Boulevard, Greenville, NC 27834, USA.
Arjun MohanDivision of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23284, USA.
Anagha MalurDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Brody School of Medicine Sciences Building, East Carolina University, Moye Boulevard, Greenville, NC 27834, USA.
Achut G MalurDepartment of Microbiology & Immunology, St. George's University, St. George 999166, Grenada.
Matthew McPeekDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Brody School of Medicine Sciences Building, East Carolina University, Moye Boulevard, Greenville, NC 27834, USA.
Barbara P BarnaDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Brody School of Medicine Sciences Building, East Carolina University, Moye Boulevard, Greenville, NC 27834, USA.
Mary Jane ThomassenDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Brody School of Medicine Sciences Building, East Carolina University, Moye Boulevard, Greenville, NC 27834, USA.
East Carolina University · USSt. George's University · GDVirginia Commonwealth University · US

Funding

Translational Research Support CoreP30ES025128 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Sue Fenton · 2015 to 2026
$18.3M
Alveolar Macrophages in Granulomatous DiseaseR01ES025191 · NIEHS · EAST CAROLINA UNIVERSITY · PI THOMASSEN, MARY JANE · 2016 to 2020
$1.6M
NIEHS NIH HHS R01 ES025191NIH HHS ES025191NIH HHS P30 ES025128
6 · The paper itself

Abstract

Sarcoidosis is a chronic disease with unknown etiology and pathophysiology, characterized by granuloma formation. Matrix Metalloproteinase-12 (MMP12) is an elastase implicated in active granulomatous sarcoidosis. Previously, we reported that oropharyngeal instillation of multiwall carbon nanotubes (MWCNT) into C57Bl/6 mice induced sarcoid-like granulomas and upregulation of MMP12. When

Indexed as

AnimalsGranulomaLung DiseasesMacrophages, AlveolarMatrix Metalloproteinase 12MiceMice, KnockoutNanotubes, Carbonmatrix metallopeptidase 12, mouseMatrix Metalloproteinase 12Nanotubes, CarbongranulomainflammationMMP12MWCNTPPARγsarcoidosis

Identifiers

PMID34681679
PMCPMC8537143
OpenAlexW3205545543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.