Evidence map›Paper›PMID 34681676›Full record

ArticleInternational journal of molecular sciences2021

Adjunctive Thymosin Beta-4 Treatment Influences MΦ Effector Cell Function to Improve Disease Outcome in

Yuxin Wang, Thomas W Carion, Abdul Shukkur Ebrahim, Gabriel Sosne, Elizabeth A Berger

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yuxin WangDepartment of Ophthalmology, Visual & Anatomical Sciences, Wayne State University School of Medicine, 540 E. Canfield Avenue, Detroit, MI 48201, USA.
Thomas W CarionDepartment of Ophthalmology, Visual & Anatomical Sciences, Wayne State University School of Medicine, 540 E. Canfield Avenue, Detroit, MI 48201, USA.
Abdul Shukkur EbrahimDepartment of Ophthalmology, Visual & Anatomical Sciences, Wayne State University School of Medicine, 540 E. Canfield Avenue, Detroit, MI 48201, USA.
Gabriel SosneDepartment of Ophthalmology, Visual & Anatomical Sciences, Wayne State University School of Medicine, 540 E. Canfield Avenue, Detroit, MI 48201, USA.ORCID 0000-0002-4805-7327
Elizabeth A BergerDepartment of Ophthalmology, Visual & Anatomical Sciences, Wayne State University School of Medicine, 540 E. Canfield Avenue, Detroit, MI 48201, USA.ORCID 0000-0001-5371-1170
Wayne State University · US

Funding

VISION RESEARCH--COREP30EY004068 · NEI · WAYNE STATE UNIVERSITY · PI LINDA D HAZLETT · 1985 to 2026
$13.2M
Thymosin beta-4 as an Adjunct Treatment for Bacterial KeratitisR01EY029836 · NEI · WAYNE STATE UNIVERSITY · PI BERGER, ELIZABETH · 2019 to 2023
$1.9M
VIP and Disease Resolution of Bacterial-Induced Ocular InfectionR01EY023226 · NEI · WAYNE STATE UNIVERSITY · PI BERGER, ELIZABETH · 2014 to 2017
$1.5M
NEI NIH HHS P30 EY004068NEI NIH HHS P30EY004068NEI NIH HHS R01EY023226NEI NIH HHS R01 EY029836Research to Prevent Blindness Unrestricted
6 · The paper itself

Abstract

Our previous work has shown that topical thymosin beta 4 (Tβ4) as an adjunct to ciprofloxacin treatment reduces inflammatory mediators and inflammatory cell infiltrates (neutrophils/PMN and macrophages/MΦ) while enhancing bacterial killing and wound healing pathway activation in an experimental model of

Indexed as

AnimalsCiprofloxacinDrug Therapy, CombinationEye Infections, BacterialFemaleInflammationKeratitisMacrophagesMiceMice, Inbred C57BLPseudomonas aeruginosaPseudomonas InfectionsRAW 264.7 CellsThymosinThymosin beta(4)CiprofloxacinThymosinThymosin beta(4)efferocytosisimmunoregulationkeratitisMΦRNSTβ4

Identifiers

PMID34681676
PMCPMC8537948
OpenAlexW3207164397

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.