Evidence map›Paper›PMID 34681582›Full record

ReviewInternational journal of molecular sciences2021

Cytokine Networks in the Pathogenesis of Rheumatoid Arthritis.

Naoki Kondo, Takeshi Kuroda, Daisuke Kobayashi

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 282 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
282citing papers in PubMed, 6 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

282 citing papers in PubMed, 6 syntheses or guidelines pooled it, 5 citations in OpenAlex.

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222 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Naoki KondoDivision of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-Dori, Chuo-ku, Niigata City 951-8510, Japan.ORCID 0000-0002-8985-3055
Takeshi KurodaHealth Administration Center, Niigata University, 2-8050 Ikarashi, Nishi-ku, Niigata City 950-2181, Japan.
Daisuke KobayashiDivision of Clinical Nephrology and Rheumatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-Dori, Chuo-ku, Niigata City 951-8510, Japan.ORCID 0000-0002-0384-8678
Niigata University Medical and Dental Hospital · JPNiigata University · JP

Funding

JSPS KAKENHI 17K09973
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic inflammation causing progressive joint damage that can lead to lifelong disability. The pathogenesis of RA involves a complex network of various cytokines and cells that trigger synovial cell proliferation and cause damage to both cartilage and bone. Involvement of the cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-6 is central to the pathogenesis of RA, but recent research has revealed that other cytokines such as IL-7, IL-17, IL-21, IL-23, granulocyte macrophage colony-stimulating factor (GM-CSF), IL-1β, IL-18, IL-33, and IL-2 also play a role. Clarification of RA pathology has led to the development of therapeutic agents such as biological disease-modifying anti-rheumatic drugs (DMARDs) and Janus kinase (JAK) inhibitors, and further details of the immunological background to RA are emerging. This review covers existing knowledge regarding the roles of cytokines, related immune cells and the immune system in RA, manipulation of which may offer the potential for even safer and more effective treatments in the future.

Indexed as

Antirheumatic AgentsArthritis, RheumatoidCytokinesEpigenesis, GeneticGranulocyte-Macrophage Colony-Stimulating FactorHumansInterleukin-6Protein Kinase InhibitorsReceptors, Tumor Necrosis FactorTumor Necrosis Factor-alphaAntirheumatic AgentsCytokinesGranulocyte-Macrophage Colony-Stimulating FactorInterleukin-6Protein Kinase InhibitorsReceptors, Tumor Necrosis FactorTumor Necrosis Factor-alphaGM-CSFIL-17IL-18IL-1βIL-2IL-21IL-23IL-33IL-6IL-7rheumatoid arthritisTNF-α

Identifiers

PMID34681582
PMCPMC8539723
OpenAlexW3190882738

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.