Evidence map›Paper›PMID 34681565›Full record

ArticleInternational journal of molecular sciences2021

Effects of Manganese on Genomic Integrity in the Multicellular Model Organism

Merle M Nicolai, Ann-Kathrin Weishaupt, Jessica Baesler, Vanessa Brinkmann, Anna Wellenberg, Nicola Winkelbeiner, Anna Gremme, Michael Aschner, Gerhard Fritz, Tanja Schwerdtle and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Dysfunctional copper homeostasis inRedox biochemistry and chemistry · 2024
    Article
  4. Consequences of Disturbing Manganese Homeostasis.International journal of molecular sciences · 2023
    Review
  5. Biomolecules · 2022
    Review
  6. Manganese-Induced Toxicity inInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Merle M NicolaiFood Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstraße 20, 42119 Wuppertal, Germany.ORCID 0000-0002-0950-4841
Ann-Kathrin WeishauptFood Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstraße 20, 42119 Wuppertal, Germany.ORCID 0000-0002-1650-7899
Jessica BaeslerTraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (FOR 2558), Berlin-Potsdam-Jena-Wuppertal, 14558 Nuthetal, Germany.
Vanessa BrinkmannInstitute of Toxicology, Medical Faculty, Heinrich Heine University Düsseldorf, Moorenstr.5, 40225 Düsseldorf, Germany.ORCID 0000-0002-2284-3143
Anna WellenbergInstitute of Toxicology, Medical Faculty, Heinrich Heine University Düsseldorf, Moorenstr.5, 40225 Düsseldorf, Germany.
Nicola WinkelbeinerTraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (FOR 2558), Berlin-Potsdam-Jena-Wuppertal, 14558 Nuthetal, Germany.ORCID 0000-0003-3455-7774
Anna GremmeFood Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstraße 20, 42119 Wuppertal, Germany.
Michael AschnerAlbert Einstein College of Medicine, Department of Molecular Pharmacology, Neuroscience and Pediatrics, Bronx, NY 10032, USA.ORCID 0000-0002-2619-1656
Gerhard FritzInstitute of Toxicology, Medical Faculty, Heinrich Heine University Düsseldorf, Moorenstr.5, 40225 Düsseldorf, Germany.
Tanja SchwerdtleTraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (FOR 2558), Berlin-Potsdam-Jena-Wuppertal, 14558 Nuthetal, Germany.
Julia BornhorstFood Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstraße 20, 42119 Wuppertal, Germany.ORCID 0000-0002-4018-2406
University of Wuppertal · DEHeinrich Heine University Düsseldorf · DEUniversity of Potsdam · DEAlbert Einstein College of Medicine · US

Funding

Deutsche Forschungsgemeinschaft BO4103/4-2, BO4103/2-1
6 · The paper itself

Abstract

Although manganese (Mn) is an essential trace element, overexposure is associated with Mn-induced toxicity and neurological dysfunction. Even though Mn-induced oxidative stress is discussed extensively, neither the underlying mechanisms of the potential consequences of Mn-induced oxidative stress on DNA damage and DNA repair, nor the possibly resulting toxicity are characterized yet. In this study, we use the model organism

Indexed as

DNA DamageAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsDNA RepairDose-Response Relationship, DrugGTPase-Activating ProteinsManganeseModels, AnimalMortalityOxidative StressPoly(ADP-ribose) PolymerasesTime FactorsCaenorhabditis elegans ProteinsGTPase-Activating ProteinsManganesePoly(ADP-ribose) PolymerasesCaenorhabditis elegansDNA damage responseDNA repairmanganeseoxidative stress

Identifiers

PMID34681565
PMCPMC8535284
OpenAlexW3205208044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.