Evidence map›Paper›PMID 34681554›Full record

ArticleFoods (Basel, Switzerland)2021

Optimisation of an Aglycone-Enhanced Celery Extract with Germinated Soy Supplementation Using Response Surface Methodology.

Hazel Lau, Hui Min Koh, Hiranya Dayal, Yi Ren, Sam Fong Yau Li

Open access · goldAbstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Hazel LauDepartment of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.
Hui Min KohDepartment of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.
Hiranya DayalDepartment of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.
Yi RenInstitute of Materials Research and Engineering, Agency for Science, Technology and Research (A∗STAR), 2 Fusionopolis Way, Innovis, #08-03, Singapore 138634, Singapore.
Sam Fong Yau LiDepartment of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.ORCID 0000-0002-2092-9226
National University of Singapore · SGAgency for Science, Technology and Research · SG

Funding

Ministry of Education R-143-000-B48-114
6 · The paper itself

Abstract

In this study, the extraction conditions of bioactive aglycones from a celery extract supplemented with germinated soy were optimised by a response surface methodology. For subsequent enzymatic hydrolysis to enhance the apigenin content, increased production of its precursor apigetrin was firstly achieved through acidic extraction at optimal conditions, involving water at pH 1, at 75 °C for 2 h. Subsequently, a central composite design was conducted to analyse the pH (3-11) and temperature (25-35 °C) effects on the aglycone levels (apigenin, daidzein and genistein). The optimal extraction conditions were pH 7.02 and 29.99 °C, which resulted in a 40-fold increase in apigenin. The novel and cost-effective application of germinated soy β-glucosidase for the conversion of aglycones in non-soy foods is demonstrated. The enhanced bioactivities of aglycones may suggest potential applications for similar formulations as functional food ingredients.

Indexed as

aglyconeapigenincelerygerminated soyresponse surface methodology

Identifiers

PMID34681554
PMCPMC8535585
OpenAlexW3207693377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.