Evidence map›Paper›PMID 34681433›Full record

ArticleFoods (Basel, Switzerland)2021

Yan Zheng, Zhongjie Yu, Wenyi Zhang, Tiansong Sun

2 registry-linked trialsAbstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07439978 phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Physiological Study of a Fermented Yogurt Drink Containing Probiotics

TypeinterventionalSponsorUniversity College DublinRan2026 to 2026Enrolled50ConditionsColonization, Asymptomatic, ColonisationArmsprobiotic containing L.rhamnosus R0011 strain, 200 ml yogurt drink
NCT07510282 phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Physiological Study on How Probiotic Delivered to the Small Intestine Changes Microbiota

TypeinterventionalSponsorUniversity College DublinRan2026 to 2026Enrolled25ConditionsColonization, Asymptomatic, ColonizationArmsProbiotic containing L.rhamnosus R0011 strain, 200 ml yogurt drink
3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Human breast milk and its impact on inflammatory bowel disease.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2025
    Review
  5. The therapeutic effects ofGut microbiome (Cambridge, England) · 2025
    Review
  6. The Consumption ofMicroorganisms · 2024
    Article
  7. Effects of Lactoferrin andAnimals : an open access journal from MDPI · 2024
    Article
  8. Article
  9. Berberine alleviates enterotoxigenicFrontiers in nutrition · 2024
    Article
  10. ProbioticsmSystems · 2023
    Article
  11. Protective Effects ofFood science of animal resources · 2023
    Article
  12. Review
  13. Molecules (Basel, Switzerland) · 2023
    Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yan ZhengKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China.ORCID 0000-0001-9393-1098
Zhongjie YuKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China.ORCID 0000-0001-6632-2641
Wenyi ZhangKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China.
Tiansong SunKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China.

Funding

National Natural Science Foundation of China 31771954
6 · The paper itself

Abstract

objectiveTo evaluate the effect of the probiotic,

methodsTwelve postgraduate student volunteers were recruited. Six volunteers received oral Probio-M9 for 21 days, while the remaining six received a placebo instead. Fecal samples were collected from the volunteers before and after the intervention. Metagenomic sequencing, nontargeted metabonomics, and quality-of-life follow-up questionnaires were used to evaluate the impact of Probio-M9 consumption on the gut microbiota and life quality of the volunteers.

resultsProbio-M9 improved the psychological and physiological quality-of-life symptoms significantly in stressed adults (

conclusionsWe identified that oral Probio-M9 can regulate the stability of gut microbiota and affect the related beneficial metabolites, thereby affecting the quality of life (QoL) of stressed adults. Probio-M9 might improve the psychological and physiological quality of life in stressed adults via the gut-brain axis pathway. The causal relationship should be further explored in future studies.

Indexed as

gut-brain axisgut microbiotaLactobacillus rhamnosusmetabolitesProbio-M9stressed adultsthe quality of life

Identifiers

PMID34681433
PMCPMC8535744

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.