Evidence map›Paper›PMID 34681298›Full record

ReviewFoods (Basel, Switzerland)2021

Bromelain, a Group of Pineapple Proteolytic Complex Enzymes (

Carolina Varilla, Massimo Marcone, Lisete Paiva, Jose Baptista

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Foods (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Investigating theResearch in pharmaceutical sciences · 2026
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  14. Combined Effects of Diosmin, Hesperidin,International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Carolina VarillaDepartment of Food Science, University of Guelph, Guelph, ON N1G 2W1, Canada.
Massimo MarconeDepartment of Food Science, University of Guelph, Guelph, ON N1G 2W1, Canada.
Lisete PaivaDepartment of Science of Physics, Chemistry and Engineering (DCFCE), Institute for Investigation and Technology of Agronomy and Environment (IITAA), University of Azores, 9500-321 Azores, Portugal.
Jose BaptistaDepartment of Science of Physics, Chemistry and Engineering (DCFCE), Institute for Investigation and Technology of Agronomy and Environment (IITAA), University of Azores, 9500-321 Azores, Portugal.
Universidade dos Açores · PTUniversity of Guelph · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bromelain is a complex combination of multiple endopeptidases of thiol and other compounds derived from the pineapple fruit, stem and/or root. Fruit bromelain and stem bromelain are produced completely distinctly and comprise unique compounds of enzymes, and the descriptor "Bromelain" originally referred in actuality to stem bromelain. Due to the efficacy of oral administration in the body, as a safe phytotherapeutic medication, bromelain was commonly suited for patients due to lack of compromise in its peptidase efficacy and the absence of undesired side effects. Various in vivo and in vitro studies have shown that they are anti-edematous, anti-inflammatory, anti-cancerous, anti-thrombotic, fibrinolytic, and facilitate the death of apoptotic cells. The pharmacological properties of bromelain are, in part, related to its arachidonate cascade modulation, inhibition of platelet aggregation, such as interference with malignant cell growth; anti-inflammatory action; fibrinolytic activity; skin debridement properties, and reduction of the severe effects of SARS-Cov-2. In this paper, we concentrated primarily on the potential of bromelain's important characteristics and meditative and therapeutic effects, along with the possible mechanism of action.

Indexed as

Ananas comosusanti-inflammatory effectbromelainclinical use of bromelainphytotherapeutic applicationspineapple plantproteinases

Identifiers

PMID34681298
PMCPMC8534447
OpenAlexW3200079410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.