Evidence map›Paper›PMID 34681272›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

SARS-CoV-2 Fears Green: The Chlorophyll Catabolite Pheophorbide A Is a Potent Antiviral.

Guillermo H Jimenez-Aleman, Victoria Castro, Addis Londaitsbehere, Marta Gutierrez-Rodríguez, Urtzi Garaigorta, Roberto Solano, Pablo Gastaminza

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Frontiers in microbiology · 2024
    Review
  8. Analysis ofFrontiers in plant science · 2024
    Review
  9. Review
  10. Article
  11. Marine drugs · 2023
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Guillermo H Jimenez-AlemanNational Centre for Biotechnology (CNB-CSIC), Department of Plant Molecular Genetics, 28049 Madrid, Spain.ORCID 0000-0002-6930-9589
Victoria CastroNational Centre for Biotechnology (CNB-CSIC), Department of Cell & Molecular Biology, 28049 Madrid, Spain.ORCID 0000-0001-9151-5138
Addis LondaitsbehereNational Centre for Biotechnology (CNB-CSIC), Department of Plant Molecular Genetics, 28049 Madrid, Spain.
Marta Gutierrez-RodríguezMedicinal Chemistry Institute (IQM-CSIC), Department of Biomimetics for Drug Discovery, 28006 Madrid, Spain.ORCID 0000-0001-9855-8341
Urtzi GaraigortaNational Centre for Biotechnology (CNB-CSIC), Department of Cell & Molecular Biology, 28049 Madrid, Spain.ORCID 0000-0002-0683-5725
Roberto SolanoNational Centre for Biotechnology (CNB-CSIC), Department of Plant Molecular Genetics, 28049 Madrid, Spain.ORCID 0000-0001-5459-2417
Pablo GastaminzaNational Centre for Biotechnology (CNB-CSIC), Department of Cell & Molecular Biology, 28049 Madrid, Spain.
Centro Nacional de Biotecnología · ES

Funding

Consejo Superior de Investigaciones Científicas CSIC-CoV19-153 ref PIE-202080E221Consejo Superior de Investigaciones Científicas PIE-RD-COVID-19 ref 202040E236Consejo Superior de Investigaciones Científicas PIE-RD-COVID-19 ref. E202020E079Deutsche Forschungsgemeinschaft JI 241/2-1european virus archive No 871029
6 · The paper itself

Abstract

SARS-CoV-2 pandemic is having devastating consequences worldwide. Although vaccination advances at good pace, effectiveness against emerging variants is unpredictable. The virus has displayed a remarkable resistance to treatments and no drugs have been proved fully effective against COVID-19. Thus, despite the international efforts, there is still an urgent need for new potent and safe antivirals against SARS-CoV-2. Here, we exploited the enormous potential of plant metabolism using the bryophyte

Indexed as

chlorophyllCOVID-19liverwortMarchantia polymorphaPheophorbide aSARS-CoV-2

Identifiers

PMID34681272
PMCPMC8538351
OpenAlexW3206022992

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.