ReviewPharmaceuticals (Basel, Switzerland)2021
Recent Developments in the Synthesis of β-Diketones.
Review in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 43 citations in OpenAlex.
- Article
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- New Strategy Based on Click Reaction for Preparation of 3-Acyl-4-hydroxycoumarin-Modified Silica as a Perspective Material for the Separation of Rare Earth Elements.Molecules (Basel, Switzerland) · 2026Article
- From β-Dicarbonyl Chemistry to Dynamic Polymers.Chemical reviews · 2025Review
- Synthesis, crystal structure and Hirshfeld surface analysis of (2-amino-benzo-thia-zole-κActa crystallographica. Section E, Crystallographic communications · 2025Article
- Seasonal Variability of Lipophilic Compounds in Oat (Journal of agricultural and food chemistry · 2024Article
- Theoretical modeling of electronic absorption spectra of ionized species of β-diketones.Journal of molecular modeling · 2024Article
- Half-Curcuminoids Encapsulated in Alginate-Glucosamine Hydrogel Matrices as Bioactive Delivery Systems.Gels (Basel, Switzerland) · 2024Article
- Design, Synthesis, and Biological Evaluation of Novel Coumarin Analogs Targeted against SARS-CoV-2.Molecules (Basel, Switzerland) · 2024Article
- Exploring C-F···π Interactions: Synthesis, Characterization, and Surface Analysis of Copper β-Diketone Complexes.ACS omega · 2024Article
- Article
- Synthesis, Anticancer, Antioxidant, Anti-Inflammatory, Antimicrobial Activities, Molecular Docking, and DFT Studies of Sultams Derived from Saccharin.Molecules (Basel, Switzerland) · 2022Article
- Asymmetric organocatalytic Michael addition of cyclopentane-1,2-dione to alkylidene oxindole.Beilstein journal of organic chemistry · 2022Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apart from being one of the most important intermediates in chemical synthesis, broadly used in the formation of C-C bonds among other processes, the β-dicarbonyl structure is present in a huge number of biologically and pharmaceutically active compounds. In fact, mainly derived from the well-known antioxidant capability associated with the corresponding enol tautomer, β-diketones are valuable compounds in the treatment of many pathological disorders, such as cardiovascular and liver diseases, hypertension, obesity, diabetes, neurological disorders, inflammation, skin diseases, fibrosis, or arthritis; therefore, the synthesis of these structures is an area of overwhelming interest for organic chemists. This paper is devoted to the advances achieved in the last ten years for the preparation of 1,3-diketones, using different chemical (Claisen, hydration of alkynones, decarboxylative coupling) or catalytic (biocatalysis, organocatalytic, metal-based catalysis) methodologies: Additionally, the preparation of branched β-dicarbonyl compounds by means of α-functionalization of non-substituted 1,3-diketones are also discussed.
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