Evidence map›Paper›PMID 34681251›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

In Silico Studies of Potential Selective Inhibitors of Thymidylate Kinase from

Danielle R Garcia, Felipe R Souza, Ana P Guimarães, Martin Valis, Zbyšek Pavelek, Kamil Kuca, Teodorico C Ramalho, Tanos C C França

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Danielle R GarciaLaboratory of Molecular Modeling Applied to Chemical and Biological Defense, Military Institute of Engineering, Praça General Tiburcio 80, Urca, Rio de Janeiro 22290-270, Brazil.
Felipe R SouzaDepartment of Chemistry, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22541-041, Brazil.ORCID 0000-0001-7410-5188
Ana P GuimarãesDepartment of Chemistry, Federal University of Viçosa, Avenida P. H. Rolfs, s/n, Centro, Viçosa 36570-000, MG, Brazil.
Martin ValisDepartment of Neurology of the Medical Faculty of Charles University and University Hospital in Hradec Kralove, Sokolska 581, 50005 Hradec Kralove, Czech Republic.
Zbyšek PavelekDepartment of Neurology of the Medical Faculty of Charles University and University Hospital in Hradec Kralove, Sokolska 581, 50005 Hradec Kralove, Czech Republic.ORCID 0000-0002-1772-8781
Kamil KucaDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 50003 Hradec Kralove, Czech Republic.ORCID 0000-0001-9664-1109
Teodorico C RamalhoDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 50003 Hradec Kralove, Czech Republic.ORCID 0000-0002-7324-1353
Tanos C C FrançaLaboratory of Molecular Modeling Applied to Chemical and Biological Defense, Military Institute of Engineering, Praça General Tiburcio 80, Urca, Rio de Janeiro 22290-270, Brazil.ORCID 0000-0002-6048-8103
Charles University · CZMilitary Institute of Engineering · BRPontifícia Universidade Católica do Rio de Janeiro · BRUniversidade Federal de Lavras · BRUniversidade Federal de Viçosa · BRUniversity Hospital Hradec Králové · CZ

Funding

Brazilian agencies Conselho Nacional de Pesquisa (CNPq) 308225/2018-0Charles University in Prague, Czech Republic PROGRES Q40Fundação de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ) E-02/202.961/2017Ministry of Health of the Czech Republic FN HK 00179906UHK VT2019-2021
6 · The paper itself

Abstract

Continuing the work developed by our research group, in the present manuscript, we performed a theoretical study of 10 new structures derived from the antivirals cidofovir and ribavirin, as inhibitor prototypes for the enzyme thymidylate kinase from

Indexed as

dockingmolecular dynamicssmallpoxthymidylate kinaseVariola virus

Identifiers

PMID34681251
PMCPMC8537287
OpenAlexW3205511507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.