Evidence map›Paper›PMID 34681248›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Identification of a Novel Neuropeptide S Receptor Antagonist Scaffold Based on the SHA-68 Core.

Allison Zarkin, Rajwana Jahan, Rajendra Uprety, Yanan Zhang, Charles McElhinny, Rodney Snyder, Elaine Gay, Gabriel Jewula, Heather Bool, Stewart D Clark and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Allison ZarkinResearch Triangle Institute, P.O. Box 12194, Research Triangle Park, NC 27709-2194, USA.
Rajwana JahanResearch Triangle Institute, P.O. Box 12194, Research Triangle Park, NC 27709-2194, USA.
Rajendra UpretyResearch Triangle Institute, P.O. Box 12194, Research Triangle Park, NC 27709-2194, USA.
Yanan ZhangResearch Triangle Institute, P.O. Box 12194, Research Triangle Park, NC 27709-2194, USA.ORCID 0000-0001-7153-4358
Charles McElhinnyResearch Triangle Institute, P.O. Box 12194, Research Triangle Park, NC 27709-2194, USA.ORCID 0000-0001-7976-1926
Rodney SnyderResearch Triangle Institute, P.O. Box 12194, Research Triangle Park, NC 27709-2194, USA.
Elaine GayResearch Triangle Institute, P.O. Box 12194, Research Triangle Park, NC 27709-2194, USA.
Gabriel JewulaDepartment of Pharmacology and Toxicology, State University of New York at Buffalo, 3435 Main Street, Buffalo, NY 14214, USA.
Heather BoolDepartment of Pharmacology and Toxicology, State University of New York at Buffalo, 3435 Main Street, Buffalo, NY 14214, USA.
Stewart D ClarkDepartment of Pharmacology and Toxicology, State University of New York at Buffalo, 3435 Main Street, Buffalo, NY 14214, USA.
Scott RunyonResearch Triangle Institute, P.O. Box 12194, Research Triangle Park, NC 27709-2194, USA.
RTI International · USUniversity at Buffalo, State University of New York · US

Funding

National Institutes of Health MH122196-02
6 · The paper itself

Abstract

Activation of the neuropeptide S receptor (NPSR) system has been shown to produce anxiolytic-like actions, arousal, and enhance memory consolidation, whereas blockade of the NPSR has been shown to reduce relapse to substances of abuse and duration of anesthetics. We report here the discovery of a novel core scaffold (+) N-benzyl-3-(2-methylpropyl)-1-oxo-3-phenyl-1H,3H,4H,5H,6H,7H-furo[3,4-c]pyridine-5-carboxamide with potent NPSR antagonist activity in vitro. Pharmacokinetic parameters demonstrate that

Indexed as

antagonistanxiolyticneuropeptide SNPSR

Identifiers

PMID34681248
PMCPMC8538004
OpenAlexW3206336239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.