Evidence map›Paper›PMID 34681245›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Design and Synthesis of Newly Synthesized Acrylamide Derivatives as Potential Chemotherapeutic Agents against MCF-7 Breast Cancer Cell Line Lodged on PEGylated Bilosomal Nano-Vesicles for Improving Cytotoxic Activity.

Islam Zaki, Reham A I Abou-Elkhair, Ali H Abu Almaaty, Ola A Abu Ali, Eman Fayad, Ahmed Gaafar Ahmed Gaafar, Mohamed Y Zakaria

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Islam ZakiPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Port Said University, Port Said 42526, Egypt.ORCID 0000-0002-2026-7373
Reham A I Abou-ElkhairApplied Nucleic Acids Research Center & Chemistry Department, Faculty of Science, Zagazig University, Zagazig 44523, Egypt.
Ali H Abu AlmaatyZoology Department, Faculty of Science, Port Said University, Port Said 42526, Egypt.ORCID 0000-0001-9056-0228
Ola A Abu AliChemistry Department, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Eman FayadBiotechnology Department, Faculty of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0003-2916-0254
Ahmed Gaafar Ahmed GaafarPharmacology and Toxicology Department, Faculty of Pharmacy, Port Said University, Port Said 42526, Egypt.
Mohamed Y ZakariaDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Port Said University, Port Said 42526, Egypt.

Funding

Taif University researchers supporting project number (TURSP-2020/220) Taif University, Taif, Saudi Arabia. TURSP-2020/220
6 · The paper itself

Abstract

Cancer is a multifaceted disease. With the development of multi drug resistance, the need for the arousal of novel targets in order to avoid these drawbacks increased. A new series of acrylamide derivatives was synthesized from starting material 4-(furan-2-ylmethylene)-2-(3,4,5-trimethoxyphenyl)oxazol-5(4

Indexed as

acrylamideannexinaqueous solubility and optimizationcell cycle analysisPEGylated bilosomestubulin

Identifiers

PMID34681245
PMCPMC8540948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.