Evidence map›Paper›PMID 34681208›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Design, Synthesis and Biological Evaluation of Aromatase Inhibitors Based on Sulfonates and Sulfonamides of Resveratrol.

Marialuigia Fantacuzzi, Marialucia Gallorini, Nicola Gambacorta, Alessandra Ammazzalorso, Zeineb Aturki, Marwa Balaha, Simone Carradori, Letizia Giampietro, Cristina Maccallini, Amelia Cataldi and 3 more

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Anticancer Activity of Natural Products and Related Compounds.International journal of molecular sciences · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Anticancer Inhibitors.Molecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marialuigia FantacuzziUnit of Medicinal Chemistry, Department of Pharmacy, "G. d'Annunzio" University, 66100 Chieti, Italy.ORCID 0000-0003-2401-7547
Marialucia GalloriniUnit of Anatomy, Department of Pharmacy, "G. d'Annunzio" University, 66100 Chieti, Italy.ORCID 0000-0002-2283-4159
Nicola GambacortaUnit of Medicinal Chemistry, Department of Pharmacy, "A. Moro" University, 70121 Bari, Italy.ORCID 0000-0003-1965-1519
Alessandra AmmazzalorsoUnit of Medicinal Chemistry, Department of Pharmacy, "G. d'Annunzio" University, 66100 Chieti, Italy.ORCID 0000-0003-4369-1772
Zeineb AturkiInstitute for Biological Systems (ISB), Italian National Research Council, Monterotondo, 00015 Rome, Italy.
Marwa BalahaUnit of Anatomy, Department of Pharmacy, "G. d'Annunzio" University, 66100 Chieti, Italy.ORCID 0000-0001-8042-6009
Simone CarradoriUnit of Medicinal Chemistry, Department of Pharmacy, "G. d'Annunzio" University, 66100 Chieti, Italy.ORCID 0000-0002-8698-9440
Letizia GiampietroUnit of Medicinal Chemistry, Department of Pharmacy, "G. d'Annunzio" University, 66100 Chieti, Italy.ORCID 0000-0002-8483-1885
Cristina MaccalliniUnit of Medicinal Chemistry, Department of Pharmacy, "G. d'Annunzio" University, 66100 Chieti, Italy.ORCID 0000-0003-2957-8650
Amelia CataldiUnit of Anatomy, Department of Pharmacy, "G. d'Annunzio" University, 66100 Chieti, Italy.
Orazio NicolottiUnit of Medicinal Chemistry, Department of Pharmacy, "A. Moro" University, 70121 Bari, Italy.ORCID 0000-0001-6533-5539
Rosa AmorosoUnit of Medicinal Chemistry, Department of Pharmacy, "G. d'Annunzio" University, 66100 Chieti, Italy.ORCID 0000-0002-8282-8535
Barbara De FilippisUnit of Medicinal Chemistry, Department of Pharmacy, "G. d'Annunzio" University, 66100 Chieti, Italy.ORCID 0000-0001-7718-5814

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A library of sulfonate and sulfonamide derivatives of Resveratrol was synthesized and tested for its aromatase inhibitory potential. Interestingly, sulfonate derivatives were found to be more active than sulfonamide bioisosteres with IC

Indexed as

aromatase inhibitorsbreast cancercytochromes P450dockingresveratrolstilbenesulfonamidessulfonates

Identifiers

PMID34681208
PMCPMC8537897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.