A Novel Statin Compound from Monacolin J Produced Using CYP102A1-Catalyzed Regioselective C-Hydroxylation.

Ngoc Tan Cao, Ngoc Anh Nguyen, Chan Mi Park, Gun Su Cha, Ki Deok Park, Chul-Ho Yun

Open access · goldAbstract read

In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.7field-weighted citation impact, top 29% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

In Combo Studies for the Optimization of 5-Aminoanthranilic Acid Derivatives as Potential Multitarget Drugs for the Management of Metabolic Syndrome.Pharmaceuticals (Basel, Switzerland) · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ngoc Tan CaoSchool of Biological Sciences and Biotechnology, Graduate School, Chonnam National University, Yongbong-ro 77, Gwangju 61186, Korea.

Ngoc Anh NguyenSchool of Biological Sciences and Technology, Chonnam National University, Yongbong-ro 77, Gwangju 61186, Korea.

Chan Mi ParkSchool of Biological Sciences and Technology, Chonnam National University, Yongbong-ro 77, Gwangju 61186, Korea.

Gun Su ChaNamhae Garlic Research Institute, 2465-8 Namhaedaero, Gyungnam 52430, Korea.ORCID 0000-0003-0598-3133

Ki Deok ParkGwangju Center, Korea Basic Science Institute, Gwangju 61186, Korea.

Chul-Ho YunSchool of Biological Sciences and Biotechnology, Graduate School, Chonnam National University, Yongbong-ro 77, Gwangju 61186, Korea.ORCID 0000-0003-2685-2968

Chonnam National University · KRGyeongnam Provincial Namhae College · KRKorea Basic Science Institute · KR

Funding

National Research Foundation of Korea NRF-2018R1A4A1023882Rural Development Administration PJ015698

6 · The paper itself

Abstract

Statins inhibit the 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA reductase), which is the rate-limiting enzyme in cholesterol biosynthesis. Statin therapy reduces morbidity and mortality in those who are at high risk of cardiovascular disease. Monacolin J is a statin compound, which is an intermediate in the lovastatin biosynthesis pathway, in the fungus

Indexed as

HMG-CoA reductasehuman liver microsomesmonacolin Jregioselective hydroxylationstatin

Identifiers

PMID34681205

DOI10.3390/ph14100981

PMCPMC8541633

OpenAlexW3204045831

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.