Evidence map›Paper›PMID 34681123›Full record

ReviewBiology2021

Extracellular Matrix Components as Diagnostic Tools in Inflammatory Bowel Disease.

Laura Golusda, Anja A Kühl, Britta Siegmund, Daniela Paclik

Abstract readReview
In one paragraph

Review in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Feasibility ofQuantitative imaging in medicine and surgery · 2023
    Article
  7. Article
  8. Frontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Laura GolusdaFreie Universität Berlin and Humboldt Universität zu Berlin, iPATH.Berlin, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, 12200 Berlin, Germany.
Anja A KühlFreie Universität Berlin and Humboldt Universität zu Berlin, iPATH.Berlin, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, 12200 Berlin, Germany.ORCID 0000-0003-2293-5387
Britta SiegmundFreie Universität Berlin and Humboldt Universität zu Berlin, Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie (einschl. Arbeitsbereich Ernährungsmedizin), Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, 12203 Berlin, Germany.
Daniela PaclikFreie Universität Berlin and Humboldt Universität zu Berlin, iPATH.Berlin, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, 12200 Berlin, Germany.ORCID 0000-0003-2791-3136

Funding

Deutsche Forschungsgemeinschaft SFB1340 TP B06Deutsche Forschungsgemeinschaft SFB1449
6 · The paper itself

Abstract

Work from the last years indicates that the extracellular matrix (ECM) plays a direct role in various cellular processes, including proliferation, migration and differentiation. Besides homeostatic processes, its regulatory function in inflammation becomes more and more evident. In inflammation, such as inflammatory bowel disease, the ECM composition is constantly remodeled, and this can result in a structuring of fistulizing disease course. Thus, tracking early ECM changes might bear the potential to predict the disease course. In this review, we provide an overview of relevant diagnostic methods, focusing on ECM changes.

Indexed as

Crohn’s diseaseelastographyextracellular matrixfibrosisglycosaminoglycanshistopathologyinflammatory bowel diseasemagnetic resonance imagingstenosisulcerative colitis

Identifiers

PMID34681123
PMCPMC8533508

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.