Evidence map›Paper›PMID 34681041›Full record

ArticleGenes2021

Association and Gene-Gene Interactions Study of Late-Onset Alzheimer's Disease in the Russian Population.

Anna Bocharova, Kseniya Vagaitseva, Andrey Marusin, Natalia Zhukova, Irina Zhukova, Larisa Minaycheva, Oksana Makeeva, Vadim Stepanov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Anna BocharovaTomsk National Research Medical Center, Research Institute of Medical Genetics, 634050 Tomsk, Russia.
Kseniya VagaitsevaTomsk National Research Medical Center, Research Institute of Medical Genetics, 634050 Tomsk, Russia.
Andrey MarusinTomsk National Research Medical Center, Research Institute of Medical Genetics, 634050 Tomsk, Russia.ORCID 0000-0002-4642-7515
Natalia ZhukovaDepartment of Neurology and Neurosurgery, Faculty of General Medicine, Siberian State Medical University, 634050 Tomsk, Russia.
Irina ZhukovaDepartment of Neurology and Neurosurgery, Faculty of General Medicine, Siberian State Medical University, 634050 Tomsk, Russia.
Larisa MinaychevaTomsk National Research Medical Center, Research Institute of Medical Genetics, 634050 Tomsk, Russia.
Oksana MakeevaNebbiolo Center for Clinical Trials, 634009 Tomsk, Russia.
Vadim StepanovTomsk National Research Medical Center, Research Institute of Medical Genetics, 634050 Tomsk, Russia.
Tomsk National Research Medical Center · RUSiberian State Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder, and represents the most common cause of dementia. In this study, we performed several different analyses to detect loci involved in development of the late onset AD in the Russian population. DNA samples from 472 unrelated subjects were genotyped for 63 SNPs using iPLEX Assay and real-time PCR. We identified five genetic loci that were significantly associated with LOAD risk for the Russian population (

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseaseAgedAged, 80 and overAge of OnsetAlzheimer DiseaseApolipoprotein E4Apolipoproteins EEpistasis, GeneticFemaleGenotypeHaplotypesHumansMaleMitochondrial Precursor Protein Import Complex ProteinsPolymorphism, Single NucleotideApoE protein, humanApolipoprotein E4Apolipoproteins EMitochondrial Precursor Protein Import Complex ProteinsTOMM40 protein, humanAlzheimer’s diseaseAPOEcase–control studyGWASSNP

Identifiers

PMID34681041
PMCPMC8535278
OpenAlexW3205052682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.