Evidence map›Paper›PMID 34681018›Full record

ArticleGenes2021

Structural Protein Analysis of Driver Gene Mutations in Conjunctival Melanoma.

Mak B Djulbegovic, Vladimir N Uversky, J William Harbour, Anat Galor, Carol L Karp

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Intrinsic disorder may drive the interaction of PROS1 and MERTK in uveal melanoma.International journal of biological macromolecules · 2023
    Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Mak B DjulbegovicBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0002-4149-7450
Vladimir N UverskyDepartment of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Bruce B. Downs Blvd., MDC07, Tampa, FL 33612, USA.ORCID 0000-0002-4037-5857
J William HarbourBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Anat GalorBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0002-3026-6155
Carol L KarpBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
University of Miami · USMoscow Institute of Physics and Technology · RU

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Victor L Perez · 2004 to 2026
$12.2M
Tear protein biomarkers of refractive surgery painR61EY032468 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI AICHER, SUE A, GALOR, ANAT · 2020 to 2022
$2.0M
Dry Eye and MicroenvironmentR01EY026174 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GALOR, ANAT, KUMAR, NARESH · 2016 to 2020
$1.9M
NEI NIH HHS P30 EY014801NEI NIH HHS R01 EY026174NEI NIH HHS R61 EY032468
6 · The paper itself

Abstract

In recent years, there has been tremendous enthusiasm with respect to detailing the genetic basis of many neoplasms, including conjunctival melanoma (CM). We aim to analyze five proteins associated with CM, namely BRAF, NRAS, c-KIT, NF1, and PTEN. We evaluated each protein for its intrinsically disordered protein regions (IDPRs) and its protein-protein interactions (PPI) with the Predictor of Natural Disordered Protein Regions (PONDR

Indexed as

Protein ConformationConjunctival NeoplasmsGTP PhosphohydrolasesHumansIntrinsically Disordered ProteinsMelanomaMembrane ProteinsMutationNeurofibromin 1Protein Interaction MapsProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-kitPTEN PhosphohydrolaseSignal TransductionBRAF protein, humanGTP PhosphohydrolasesIntrinsically Disordered ProteinsKIT protein, humanMembrane ProteinsNeurofibromin 1NF1 protein, humanNRAS protein, humanProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-kitPTEN PhosphohydrolasePTEN protein, humanconjunctival melanomageneticsintrinsically disordered proteinsmitogen-activated protein kinase (MAPK)neuroblastoma v-ras oncogene homolog (NRAS)neurofibromatosis type 1 (NF1)phosphate and tensin homolog (PTEN)Phosphatidylinositol-3-Kinase and Protein Kinase B (PI3K-akt)proto-oncogene B-Raf (BRAF)receptor tyrosine kinase (c-KIT)structural analysistargeted therapies

Identifiers

PMID34681018
PMCPMC8535873
OpenAlexW3207633257

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.