Evidence map›Paper›PMID 34680905›Full record

ReviewGenes2021

Machine Learning: An Overview and Applications in Pharmacogenetics.

Giovanna Cilluffo, Salvatore Fasola, Giuliana Ferrante, Velia Malizia, Laura Montalbano, Stefania La Grutta

Abstract readReview
In one paragraph

Review in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. A Perspective on Artificial Intelligence for Molecular Pathologists.The Journal of molecular diagnostics : JMD · 2025
    Review
  3. Article
  4. Review
  5. Article
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  8. Review
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Giovanna CilluffoInstitute for Biomedical Research and Innovation, National Research Council, 90146 Palermo, Italy.ORCID 0000-0003-4305-3981
Salvatore FasolaInstitute for Biomedical Research and Innovation, National Research Council, 90146 Palermo, Italy.ORCID 0000-0002-5378-5505
Giuliana FerranteDepartment of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Pediatric Division, University of Verona, 37134 Verona, Italy.
Velia MaliziaInstitute for Biomedical Research and Innovation, National Research Council, 90146 Palermo, Italy.
Laura MontalbanoInstitute for Biomedical Research and Innovation, National Research Council, 90146 Palermo, Italy.
Stefania La GruttaInstitute for Biomedical Research and Innovation, National Research Council, 90146 Palermo, Italy.ORCID 0000-0001-8026-0715

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This narrative review aims to provide an overview of the main Machine Learning (ML) techniques and their applications in pharmacogenetics (such as antidepressant, anti-cancer and warfarin drugs) over the past 10 years. ML deals with the study, the design and the development of algorithms that give computers capability to learn without being explicitly programmed. ML is a sub-field of artificial intelligence, and to date, it has demonstrated satisfactory performance on a wide range of tasks in biomedicine. According to the final goal, ML can be defined as Supervised (SML) or as Unsupervised (UML). SML techniques are applied when prediction is the focus of the research. On the other hand, UML techniques are used when the outcome is not known, and the goal of the research is unveiling the underlying structure of the data. The increasing use of sophisticated ML algorithms will likely be instrumental in improving knowledge in pharmacogenetics.

Indexed as

Machine LearningComputational BiologyPharmacogeneticspharmacogeneticssupervised machine learningunsupervised machine learning

Identifiers

PMID34680905
PMCPMC8535911

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.