Evidence map›Paper›PMID 34680783›Full record

ArticleAntibiotics (Basel, Switzerland)2021

Exposure to Bacteriophages T4 and M13 Increases Integrin Gene Expression and Impairs Migration of Human PC-3 Prostate Cancer Cells.

Swapnil Ganesh Sanmukh, Nilton J Santos, Caroline Nascimento Barquilha, Sérgio Alexandre Alcantara Dos Santos, Bruno Oliveira Silva Duran, Flávia Karina Delella, Andrei Moroz, Luis Antonio Justulin, Hernandes F Carvalho, Sérgio Luis Felisbino

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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  10. Review
  11. APTC-C-SA01: A Novel Bacteriophage Cocktail TargetingInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Swapnil Ganesh SanmukhLaboratory of Extracellular Matrix Biology, Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Sao Paulo State University (UNESP), Botucatu 18618-689, SP, Brazil.ORCID 0000-0001-6827-7960
Nilton J SantosLaboratory of Extracellular Matrix Biology, Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Sao Paulo State University (UNESP), Botucatu 18618-689, SP, Brazil.ORCID 0000-0002-8549-7436
Caroline Nascimento BarquilhaLaboratory of Extracellular Matrix Biology, Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Sao Paulo State University (UNESP), Botucatu 18618-689, SP, Brazil.ORCID 0000-0001-7221-4460
Sérgio Alexandre Alcantara Dos SantosLaboratory of Extracellular Matrix Biology, Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Sao Paulo State University (UNESP), Botucatu 18618-689, SP, Brazil.
Bruno Oliveira Silva DuranDepartment of Histology, Embryology and Cell Biology, Institute of Biological Sciences, Federal University of Goiás (UFG), Goiânia 74690-900, GO, Brazil.ORCID 0000-0002-7920-8175
Flávia Karina DelellaLaboratory of Extracellular Matrix Biology, Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Sao Paulo State University (UNESP), Botucatu 18618-689, SP, Brazil.
Andrei MorozLaboratory of Monoclonal Antibodies, Department of Clinical Analysis, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Araraquara 14800-903, SP, Brazil.
Luis Antonio JustulinLaboratory of Extracellular Matrix Biology, Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Sao Paulo State University (UNESP), Botucatu 18618-689, SP, Brazil.ORCID 0000-0001-6142-3515
Hernandes F CarvalhoLaboratory of Extracellular Matrix and Gene Regulation, Department of Structural and Functional Biology, Institute of Biology, State University of Campinas, Campinas 13083-970, SP, Brazil.ORCID 0000-0002-3080-9447
Sérgio Luis FelisbinoLaboratory of Extracellular Matrix Biology, Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Sao Paulo State University (UNESP), Botucatu 18618-689, SP, Brazil.ORCID 0000-0002-6870-5192
Universidade Estadual Paulista (Unesp) · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal de Goiás · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 310805/2018-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior number 96314-2Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/19644-1Fundação de Amparo à Pesquisa do Estado de São Paulo number 2016/09532-3
6 · The paper itself

Abstract

The interaction between bacteriophages and integrins has been reported in different cancer cell lines, and efforts have been undertaken to understand these interactions in tumor cells along with their possible role in gene alterations, with the aim to develop new cancer therapies. Here, we report that the non-specific interaction of T4 and M13 bacteriophages with human PC-3 cells results in differential migration and varied expression of different integrins. PC-3 tumor cells (at 70% confluence) were exposed to 1 × 10

Indexed as

bacteriophagecell migrationintegrinnanoparticlePC-3prostate cancer

Identifiers

PMID34680783
PMCPMC8532711
OpenAlexW3202012147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.