Evidence map›Paper›PMID 34680557›Full record

ArticleBiomedicines2021

Combined Metabolic Activators Decrease Liver Steatosis by Activating Mitochondrial Metabolism in Hamsters Fed with a High-Fat Diet.

Hong Yang, Jordi Mayneris-Perxachs, Noemí Boqué, Josep M Del Bas, Lluís Arola, Meng Yuan, Hasan Türkez, Mathias Uhlén, Jan Borén, Cheng Zhang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 5 countries.

Hong YangScience for Life Laboratory, KTH Royal Institute of Technology, SE-17165 Stockholm, Sweden.
Jordi Mayneris-PerxachsDepartment of Diabetes, Endocrinology and Nutrition, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Doctor Josep Trueta, 17190 Girona, Spain.ORCID 0000-0003-3788-3815
Noemí BoquéEurecat, Centre Tecnològic de Catalunya, Technological Unit of Nutrition and Health, 43204 Reus, Spain.ORCID 0000-0001-7173-5512
Josep M Del BasEurecat, Centre Tecnològic de Catalunya, Technological Unit of Nutrition and Health, 43204 Reus, Spain.
Lluís ArolaEurecat, Centre Tecnològic de Catalunya, Technological Unit of Nutrition and Health, 43204 Reus, Spain.ORCID 0000-0003-2767-1974
Meng YuanScience for Life Laboratory, KTH Royal Institute of Technology, SE-17165 Stockholm, Sweden.
Hasan TürkezDepartment of Medical Biology, Faculty of Medicine, Atatürk University, Erzurum 25030, Turkey.ORCID 0000-0002-7046-8990
Mathias UhlénScience for Life Laboratory, KTH Royal Institute of Technology, SE-17165 Stockholm, Sweden.
Jan BorénDepartment of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, SE-40233 Gothenburg, Sweden.ORCID 0000-0003-0786-8091
Cheng ZhangScience for Life Laboratory, KTH Royal Institute of Technology, SE-17165 Stockholm, Sweden.ORCID 0000-0002-3721-8586
Adil MardinogluScience for Life Laboratory, KTH Royal Institute of Technology, SE-17165 Stockholm, Sweden.ORCID 0000-0002-4254-6090
Antoni CaimariEurecat, Centre Tecnològic de Catalunya, Technological Unit of Nutrition and Health, 43204 Reus, Spain.ORCID 0000-0001-6144-0294
Science for Life Laboratory · SETechnological Center of Nutrition and Health · ESAtatürk University · TRInstituto de Salud Carlos III · ESKing's College London · GBSahlgrenska University Hospital · SE

Funding

Agència per a la Competitivitat de l'Empresa TECCT11-1-0012Centro para el Desarrollo Tecnológico Industrial TECNOMIFOOD projectKnut och Alice Wallenbergs Stiftelse 72110
6 · The paper itself

Abstract

Although the prevalence of non-alcoholic fatty liver disease (NAFLD) continues to increase, there is no effective treatment approved for this condition. We previously showed, in high-fat diet (HFD)-fed mice, that the supplementation of combined metabolic activators (CMA), including nicotinamide riboside (NAD

Indexed as

combined metabolic activatorsmitochondrial metabolismNAFLDtranscriptomics

Identifiers

PMID34680557
PMCPMC8533474
OpenAlexW3207690913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.