Evidence map›Paper›PMID 34680485›Full record

ArticleBiomedicines2021

Transcriptional Profiling of Tumorspheres Reveals TRPM4 as a Novel Stemness Regulator in Breast Cancer.

John Verigos, Dimitris Kordias, Styliani Papadaki, Angeliki Magklara

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

John VerigosInstitute of Molecular Biology and Biotechnology-Foundation for Research and Technology, 45110 Ioannina, Greece.
Dimitris KordiasInstitute of Molecular Biology and Biotechnology-Foundation for Research and Technology, 45110 Ioannina, Greece.
Styliani PapadakiDepartment of Clinical Chemistry, Faculty of Medicine, University of Ioannina, 45110 Ioannina, Greece.
Angeliki MagklaraInstitute of Molecular Biology and Biotechnology-Foundation for Research and Technology, 45110 Ioannina, Greece.ORCID 0000-0003-3408-6722
University of Ioannina · GR

Funding

European Regional Development Fund MIS5002469
6 · The paper itself

Abstract

Cancer stem cells (CSCs) have been implicated in the development of chemoresistance, tumor recurrence and metastasis in breast cancer, thus emerging as a promising target for novel therapies. To identify novel stemness regulators that could potentially be targeted in luminal ER

Indexed as

breast cancer stem cellscombination therapymammospheresRNA-sequencingstemness markertargeted therapytransient receptor potential cation channel subfamily M member 4 (TRPM4)tumorspheres

Identifiers

PMID34680485
PMCPMC8533210
OpenAlexW3202082405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.