Evidence map›Paper›PMID 34680425›Full record

ReviewBiomedicines2021

Cross Talk of Macrophages with Tumor Microenvironment Cells and Modulation of Macrophages in Cancer by Virotherapy.

Sarah Di Somma, Fabiana Napolitano, Giuseppe Portella, Anna Maria Malfitano

Abstract readReview
In one paragraph

Review in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. The Role of miR-138 in Cardiovascular Diseases.BioMed research international · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Combination ofCells · 2022
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sarah Di SommaDipartimento di Scienze Mediche Traslazionali, Università di Napoli Federico II, 80131 Napoli, Italy.
Fabiana NapolitanoDipartimento di Scienze Mediche Traslazionali, Università di Napoli Federico II, 80131 Napoli, Italy.ORCID 0000-0002-9242-6046
Giuseppe PortellaDipartimento di Scienze Mediche Traslazionali, Università di Napoli Federico II, 80131 Napoli, Italy.
Anna Maria MalfitanoDipartimento di Scienze Mediche Traslazionali, Università di Napoli Federico II, 80131 Napoli, Italy.ORCID 0000-0002-6193-2835

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular compartments constituting the tumor microenvironment including immune cells, fibroblasts, endothelial cells, and mesenchymal stromal/stem cells communicate with malignant cells to orchestrate a series of signals that contribute to the evolution of the tumor microenvironment. In this study, we will focus on the interplay in tumor microenvironment between macrophages and mesenchymal stem cells and macrophages and fibroblasts. In particular, cell-cell interaction and mediators secreted by these cells will be examined to explain pro/anti-tumor phenotypes induced in macrophages. Nonetheless, in the context of virotherapy, the response of macrophages as a consequence of treatment with oncolytic viruses will be analyzed regarding their polarization status and their pro/anti-tumor response.

Indexed as

cancerfibroblastsmacrophagesmesenchymal stem cellstumor microenvironmentvirotherapy

Identifiers

PMID34680425
PMCPMC8533595

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.