Evidence map›Paper›PMID 34680421›Full record

ArticleBiomedicines2021

Computationally Assisted Lead Optimization of Novel Potent and Selective MAO-B Inhibitors.

Vedanjali Gogineni, Manal A Nael, Narayan D Chaurasiya, Khaled M Elokely, Christopher R McCurdy, John M Rimoldi, Stephen J Cutler, Babu L Tekwani, Francisco León

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Vedanjali GogineniDepartment of BioMolecular Sciences, Division of Medicinal Chemistry, University of Mississippi, Oxford, MS 38677, USA.
Manal A NaelDepartment of Chemistry, Institute for Computational Molecular Science, Temple University, Philadelphia, PA 19122, USA.
Narayan D ChaurasiyaDivision of Drug Discovery, Southern Research, Birmingham, AL 35205, USA.
Khaled M ElokelyDepartment of Chemistry, Institute for Computational Molecular Science, Temple University, Philadelphia, PA 19122, USA.ORCID 0000-0002-2394-021X
Christopher R McCurdyDepartment of BioMolecular Sciences, Division of Medicinal Chemistry, University of Mississippi, Oxford, MS 38677, USA.
John M RimoldiDepartment of BioMolecular Sciences, Division of Medicinal Chemistry, University of Mississippi, Oxford, MS 38677, USA.
Stephen J CutlerDepartment of BioMolecular Sciences, Division of Medicinal Chemistry, University of Mississippi, Oxford, MS 38677, USA.
Babu L TekwaniDivision of Drug Discovery, Southern Research, Birmingham, AL 35205, USA.ORCID 0000-0003-4545-4316
Francisco LeónDepartment of BioMolecular Sciences, Division of Medicinal Chemistry, University of Mississippi, Oxford, MS 38677, USA.ORCID 0000-0002-5064-2381
Southern Research Institute · USTanta University · EGUniversity of South Carolina · USMedical University of South Carolina · USUniversity of Florida · USUniversity of Mississippi · US

Funding

Center of Research Excellence in Natural Products Neuroscience (CORE-NPN)P20GM104932 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI MAJUMDAR, SOUMYAJIT · 2012 to 2016
$10.0M
Pilot Project ProgramP30GM122733 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI WILLETT, KRISTINE L · 2018 to 2022
$5.3M
National Institute of General Medical Sciences P20GM104932National Institute of General Medical Sciences P30GM122733
6 · The paper itself

Abstract

A series of dietary flavonoid acacetin 7-

Indexed as

acacetindockingflavonoidsmonoamine oxidases A and BParkinson’s Disease

Identifiers

PMID34680421
PMCPMC8533211
OpenAlexW3203148744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.