Evidence map›Paper›PMID 34680387›Full record

ArticleCancers2021

Precision Oncology of High-Grade Ovarian Cancer Defined through Targeted Sequencing.

Sandra Wessman, Beatriz Bohorquez Fuentes, Therese Törngren, Anders Kvist, Georgia Kokaraki, Hanna Menkens, Elisabet Hjerpe, Ythalo Hugo, Tirzah Braz Petta, Åke Borg and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Sandra WessmanDepartment of Oncology-Pathology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.ORCID 0000-0002-2035-2092
Beatriz Bohorquez FuentesDepartment of Oncology-Pathology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
Therese TörngrenDepartment of Clinical Sciences, Lund University, SE-223 81 Lund, Sweden.
Anders KvistDepartment of Clinical Sciences, Lund University, SE-223 81 Lund, Sweden.ORCID 0000-0002-1358-0695
Georgia KokarakiDepartment of Oncology-Pathology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
Hanna MenkensDepartment of Oncology-Pathology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
Elisabet HjerpeVisby Lasarett, SE-621 55 Visby, Sweden.ORCID 0000-0001-9456-5392
Ythalo HugoInstitute of Education, Research and Invention, Liga Contra o Câncer, Natal 59075-740, RN, Brazil.
Tirzah Braz PettaDepartment of Pathology and Laboratory Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Åke BorgDepartment of Clinical Sciences, Lund University, SE-223 81 Lund, Sweden.
Joseph W CarlsonDepartment of Oncology-Pathology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
Karolinska Institutet · SELund University · SEUniversity of Southern California · USVisby lasarett · SE

Funding

Barncancerfonden PR2019-0026Radium Hemmets Research Funds 174053Swedish Cancer Society 20 0842 PjF
6 · The paper itself

Abstract

backgroundWe examined whether molecular characterization of high-grade epithelial ovarian cancer can inform the diagnosis and/or identify potential actionable targets.

methodsAll of the consecutively sequenced high-grade ovarian tumours with consent between 2014 until 2019 were included. A total of 274 tumours underwent next generation sequencing using a targeted panel.

resultsPatients with high-grade ovarian epithelial cancer were consented to prospective molecular characterization. Clinical information was extracted from their medical record. Tumour DNA was subjected to sequencing, and selected patients received PARP inhibitor therapy.

conclusionsTumours from 274 women were sequenced, including high-grade serous carcinoma (

Indexed as

geneticsgenomicsovarian cancertargeted therapy

Identifiers

PMID34680387
PMCPMC8534266
OpenAlexW3206241524

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.