ArticleCancers2021
Impact of the Presenting Symptom on Time Intervals and Diagnostic Routes of Patients with Symptomatic Oral Cancer.
Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Patient and System Barriers to Early Diagnosis of Oral Cancer in the UK.Oral diseases · 2026Pooled it
- Primary Care Referral Delays in Oral Cancer Diagnosis: A Meta-Analysis.Oral diseases · 2025Pooled it
- The duration of intervals on the oral cancer care pathway and implications for survival: a systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- Patient delay in oral cancer in North-Western Spain: Where do we stand?Medicina oral, patologia oral y cirugia bucal · 2026Observational
- Observational
- An Analysis of the Timeline to Diagnosis and Treatment in Oral Cavity and Oropharynx Cancer.Oral diseases · 2026Article
- Can oral cancer screening reduce late-stage diagnosis, treatment delay and mortality? A population-based study in Taiwan.BMJ open · 2024Article
- Patients journey to diagnosis and treatment of oral mucosal lesions: A report on three cases.Clinical case reports · 2024Article
- Article
- Factors related to the waiting time for scheduling an oral biopsy in Brazil: a multilevel analysis.BMC health services research · 2023Observational
- Early Diagnosis and Diagnostic Delay in Oral Cancer.Cancers · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
This investigation was aimed at determining the time intervals from the presenting symptoms until the beginning of oral cancer treatment and their relative contribution to the total time, and to assess the impact of the presenting symptom on diagnostic timelines and patient referral routes. A cross-sectional, ambispective study was designed to investigate symptomatic incident cases. The Aarhus statement was used as a conceptual framework. Strategies for minimizing potential recall biases were implemented. A sample of 181 patients was recruited (power: 99.5%; α = 0.05). The patient interval reached 58.2 days (95% CI, 40.3-76.2), which accounted for 74% of the whole prereferral interval and for more than one third of the total time interval. The presenting symptom (trigger for consultation) influenced both the number of primary care consultations and the length of time to diagnosis. General dental practitioners generated longer intervals to diagnosis (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.