Evidence map›Paper›PMID 34680292›Full record

ArticleCancers2021

Limited Predictive or Prognostic Role of Tumor-Infiltrating Tissue-Resident Memory CD8 T Cells in Patients with Hepatocellular Carcinoma Receiving Immunotherapy.

Ying-Chun Shen, Ching-Ping Yeh, Yung-Ming Jeng, Chiun Hsu, Chih-Hung Hsu, Zhong-Zhe Lin, Yu-Yun Shao, Li-Chun Lu, Tsung-Hao Liu, Chien-Hung Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ying-Chun ShenDepartment of Medical Oncology, National Taiwan University Cancer Center, Taipei 10672, Taiwan.
Ching-Ping YehDepartment of Oncology, National Taiwan University Hospital, Taipei 10002, Taiwan.
Yung-Ming JengDepartment of Pathology, National Taiwan University Hospital, Taipei 10002, Taiwan.
Chiun HsuDepartment of Medical Oncology, National Taiwan University Cancer Center, Taipei 10672, Taiwan.
Chih-Hung HsuDepartment of Oncology, National Taiwan University Hospital, Taipei 10002, Taiwan.
Zhong-Zhe LinDepartment of Medical Oncology, National Taiwan University Cancer Center, Taipei 10672, Taiwan.
Yu-Yun ShaoDepartment of Oncology, National Taiwan University Hospital, Taipei 10002, Taiwan.ORCID 0000-0001-7334-1912
Li-Chun LuDepartment of Oncology, National Taiwan University Hospital, Taipei 10002, Taiwan.
Tsung-Hao LiuDepartment of Oncology, National Taiwan University Hospital, Taipei 10002, Taiwan.
Chien-Hung ChenDepartment of Internal Medicine, National Taiwan University Hospital, Taipei 10002, Taiwan.
Ann-Lii ChengDepartment of Medical Oncology, National Taiwan University Cancer Center, Taipei 10672, Taiwan.

Funding

Ministry of Education, Taiwan NTU-109L901403
6 · The paper itself

Abstract

purposeTumor-infiltrating tissue-resident memory CD8 T cells (CD8 T EXPERIMENTAL

designConsecutive HCC patients who received ICB in prospective trials were analyzed. Formalin-fixed paraffin-embedded tumor sections were stained for DAPI, CD8, CD103, CD39, programmed cell death-1 (PD-1), and programmed cell death ligand 1 (PD-L1) using a multiplex immunohistochemical method. The densities of CD8 T cells, CD8 T

resultsA total of 73 patients were identified, and 48 patients with adequate pretreatment tumor specimens and complete follow-up were analyzed. A median of 32.7% (range: 0-92.6%) of tumor-infiltrating CD8 T cells were T

conclusionsCompared with total tumor-infiltrating CD8 T cells, tumor-infiltrating CD8 T

Indexed as

hepatocellular carcinomaimmune checkpoint blockadeimmunotherapytissue-resident memory CD8 T cells

Identifiers

PMID34680292
PMCPMC8533865

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.