Evidence map›Paper›PMID 34680277›Full record

ArticleCancers2021

A Real-World Application of Liquid Biopsy in Metastatic Colorectal Cancer: The Poseidon Study.

Letizia Procaccio, Francesca Bergamo, Francesca Daniel, Cosimo Rasola, Giada Munari, Paola Biason, Stefania Crucitta, Giulia Barsotti, Giulia Zanella, Valentina Angerilli and 9 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Characterization of Plasma Cell-Free DNA Variants as of Tumor or Clonal Hematopoiesis Origin in 16,812 Advanced Cancer Patients.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  4. Review
  5. Review
  6. The ideal reporting ofPathologica · 2023
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Letizia ProcaccioOncology Unit 1, Department of Oncology, Veneto Institute of Oncology-IRCCS, 35128 Padova, Italy.ORCID 0000-0001-6626-7048
Francesca BergamoOncology Unit 1, Department of Oncology, Veneto Institute of Oncology-IRCCS, 35128 Padova, Italy.
Francesca DanielOncology Unit 1, Department of Oncology, Veneto Institute of Oncology-IRCCS, 35128 Padova, Italy.
Cosimo RasolaOncology Unit 1, Department of Oncology, Veneto Institute of Oncology-IRCCS, 35128 Padova, Italy.
Giada MunariSurgical Pathology Unit, Department of Medicine (DIMED), University of Padova, 35121 Padova, Italy.
Paola BiasonOncology Unit 1, Department of Oncology, Veneto Institute of Oncology-IRCCS, 35128 Padova, Italy.ORCID 0000-0002-2298-101X
Stefania CrucittaClinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, 56121 Pisa, Italy.
Giulia BarsottiOncology Unit 1, Department of Oncology, Veneto Institute of Oncology-IRCCS, 35128 Padova, Italy.
Giulia ZanellaOncology Unit 1, Department of Oncology, Veneto Institute of Oncology-IRCCS, 35128 Padova, Italy.
Valentina AngerilliSurgical Pathology Unit, Department of Medicine (DIMED), University of Padova, 35121 Padova, Italy.
Cristina MagroOncology Unit 1, Department of Oncology, Veneto Institute of Oncology-IRCCS, 35128 Padova, Italy.
Silvia PaccagnellaSurgical Pathology Unit, Department of Medicine (DIMED), University of Padova, 35121 Padova, Italy.
Veronica Di AntonioOncology Unit 1, Department of Oncology, Veneto Institute of Oncology-IRCCS, 35128 Padova, Italy.
Fotios LoupakisOncology Unit 1, Department of Oncology, Veneto Institute of Oncology-IRCCS, 35128 Padova, Italy.
Romano DanesiClinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, 56121 Pisa, Italy.
Vittorina ZagonelOncology Unit 1, Department of Oncology, Veneto Institute of Oncology-IRCCS, 35128 Padova, Italy.
Marzia Del ReClinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, 56121 Pisa, Italy.ORCID 0000-0001-7343-6161
Sara LonardiOncology Unit 3, Department of Oncology, Veneto Institute of Oncology-IRCCS, 35128 Padova, Italy.ORCID 0000-0002-7593-8138
Matteo FassanSurgical Pathology Unit, Department of Medicine (DIMED), University of Padova, 35121 Padova, Italy.
Istituto Oncologico Veneto · ITUniversity of Padua · ITAzienda Ospedaliera Universitaria Pisana · IT

Funding

Veneto Region and Italian Health Ministry's research program NET-2016-02363853; RP-2014-00000395
6 · The paper itself

Abstract

backgroundFirst-line decision making is the key to the successful care of mCRC patients and

methodsA monoinstitutional prospective head-to-head comparison of LB versus (vs.) STB testing was performed in a real-world setting. Selection criteria included: mCRC diagnosis with unknown

resultsA total of 33 mCRC patients were included. Mean T1 and T2 was 7 and 22 days (d), respectively (

conclusionsFaster turnaround time, high concordance and accuracy are three key points supporting the adoption of LB in routinary mCRC care, in particular when decision on first-line therapy is urgent and tissue recovery from external centers may require a long time. Results should be interpreted with caution in LB wild-type cases with low tumor burden.

Indexed as

accuracyconcordancefirst-line therapyliquid biopsymetastatic colorectal cancerreal-worldturnaround time

Identifiers

PMID34680277
PMCPMC8533756
OpenAlexW3206440885

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.