Evidence map›Paper›PMID 34680240›Full record

ArticleCancers2021

Potential Morbidity Reduction for Lung Stereotactic Body Radiation Therapy Using Respiratory Gating.

Kim Melanie Kraus, Cristoforo Simonetto, Pavel Kundrát, Vanessa Waitz, Kai Joachim Borm, Stephanie Elisabeth Combs

Abstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kim Melanie KrausSchool of Medicine and Klinikum Rechts der Isar, Department of Radiation Oncology, Technical University of Munich (TUM), 81675 Munich, Germany.ORCID 0000-0003-3359-2316
Cristoforo SimonettoDepartment of Radiation Sciences (DRS), Institute of Radiation Medicine (IRM), Helmholtz Zentrum München (HMGU), 85764 Neuherberg, Germany.ORCID 0000-0003-4816-3514
Pavel KundrátDepartment of Radiation Dosimetry, Nuclear Physics Institute of the Czech Academy of Sciences, 180 00 Prague, Czech Republic.ORCID 0000-0001-9295-6509
Vanessa WaitzSchool of Medicine and Klinikum Rechts der Isar, Department of Radiation Oncology, Technical University of Munich (TUM), 81675 Munich, Germany.
Kai Joachim BormSchool of Medicine and Klinikum Rechts der Isar, Department of Radiation Oncology, Technical University of Munich (TUM), 81675 Munich, Germany.
Stephanie Elisabeth CombsSchool of Medicine and Klinikum Rechts der Isar, Department of Radiation Oncology, Technical University of Munich (TUM), 81675 Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the potential of respiratory gating to mitigate the motion-caused misdosage in lung stereotactic body radiotherapy (SBRT). For fourteen patients with lung tumors, we investigated treatment plans for a gating window (GW) including three breathing phases around the maximum exhalation phase, GW40-60. For a subset of six patients, we also assessed a preceding three-phase GW20-40 and six-phase GW20-70. We analyzed the target volume, lung, esophagus, and heart doses. Using normal tissue complication probability (NTCP) models, we estimated radiation pneumonitis and esophagitis risks. Compared to plans without gating, GW40-60 significantly reduced doses to organs at risk without impairing the tumor doses. On average, the mean lung dose decreased by 0.6 Gy (

Indexed as

lung cancermotion managementradiation toxicityradiotherapy treatment planningSBRT

Identifiers

PMID34680240
PMCPMC8533802

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.