Evidence map›Paper›PMID 34680193›Full record

ReviewCancers2021

(In)Distinctive Role of Long Non-Coding RNAs in Common and Rare Ovarian Cancers.

Maja Sabol, Jean Calleja-Agius, Riccardo Di Fiore, Sherif Suleiman, Sureyya Ozcan, Mark P Ward, Petar Ozretić

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. The lncRNA Gm8097 is associated with hypospermatogenesis.Clinical and experimental reproductive medicine · 2024
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 5 countries.

Maja SabolLaboratory for Hereditary Cancer, Division of Molecular Medicine, Ruđer Bošković Institute, HR-10000 Zagreb, Croatia.ORCID 0000-0001-6968-2327
Jean Calleja-AgiusDepartment of Anatomy, Faculty of Medicine and Surgery, University of Malta, MSD 2080 Msida, Malta.ORCID 0000-0001-6369-0297
Riccardo Di FioreDepartment of Anatomy, Faculty of Medicine and Surgery, University of Malta, MSD 2080 Msida, Malta.ORCID 0000-0003-4905-6948
Sherif SuleimanDepartment of Anatomy, Faculty of Medicine and Surgery, University of Malta, MSD 2080 Msida, Malta.
Sureyya OzcanDepartment of Chemistry, Middle East Technical University (METU), 06800 Ankara, Turkey.ORCID 0000-0002-9371-3696
Mark P WardDepartment of Histopathology, Trinity St James's Cancer Institute, Emer Casey Molecular Pathology Laboratory, Trinity College Dublin and Coombe Women's and Infants University Hospital, D08 RX0X Dublin, Ireland.ORCID 0000-0002-9356-7246
Petar OzretićLaboratory for Hereditary Cancer, Division of Molecular Medicine, Ruđer Bošković Institute, HR-10000 Zagreb, Croatia.ORCID 0000-0001-9757-6636
University of Malta · MTRuđer Bošković Institute · HRMiddle East Technical University · TRTrinity College Dublin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rare ovarian cancers (ROCs) are OCs with an annual incidence of fewer than 6 cases per 100,000 women. They affect women of all ages, but due to their low incidence and the potential clinical inexperience in management, there can be a delay in diagnosis, leading to a poor prognosis. The underlying causes for these tumors are varied, but generally, the tumors arise due to alterations in gene/protein expression in cellular processes that regulate normal proliferation and its checkpoints. Dysregulation of the cellular processes that lead to cancer includes gene mutations, epimutations, non-coding RNA (ncRNA) regulation, posttranscriptional and posttranslational modifications. Long non-coding RNA (lncRNA) are defined as transcribed RNA molecules, more than 200 nucleotides in length which are not translated into proteins. They regulate gene expression through several mechanisms and therefore add another level of complexity to the regulatory mechanisms affecting tumor development. Since few studies have been performed on ROCs, in this review we summarize the mechanisms of action of lncRNA in OC, with an emphasis on ROCs.

Indexed as

ceRNAcompeting endogenous RNAlncRNA-based therapylncRNAslong non-coding RNAsMALAT1ovarian cancer biomarkersrare ovarian cancers

Identifiers

PMID34680193
PMCPMC8534192
OpenAlexW3205150733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.