Evidence map›Paper›PMID 34680161›Full record

ArticleBiomolecules2021

Pharmacological Inhibition of the VCP/Proteasome Axis Rescues Photoreceptor Degeneration in RHO

Merve Sen, Oksana Kutsyr, Bowen Cao, Sylvia Bolz, Blanca Arango-Gonzalez, Marius Ueffing

Abstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Mutant dominant-negativeFrontiers in molecular biosciences · 2024
    Article
  7. Review
  8. Review
  9. Article
  10. Proteostasis in aging-associated ocular disease.Molecular aspects of medicine · 2022
    Review
  11. Frontiers in neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Merve SenCentre of Ophthalmology, Institute for Ophthalmic Research, Elfriede-Aulhorn-Strasse 7, 72076 Tübingen, Germany.ORCID 0000-0002-5295-4493
Oksana KutsyrDepartment of Physiology, Genetics and Microbiology, University of Alicante, E-03080 Alicante, Spain.ORCID 0000-0002-1173-6916
Bowen CaoCentre of Ophthalmology, Institute for Ophthalmic Research, Elfriede-Aulhorn-Strasse 7, 72076 Tübingen, Germany.
Sylvia BolzCentre of Ophthalmology, Institute for Ophthalmic Research, Elfriede-Aulhorn-Strasse 7, 72076 Tübingen, Germany.
Blanca Arango-GonzalezCentre of Ophthalmology, Institute for Ophthalmic Research, Elfriede-Aulhorn-Strasse 7, 72076 Tübingen, Germany.ORCID 0000-0002-9045-182X
Marius UeffingCentre of Ophthalmology, Institute for Ophthalmic Research, Elfriede-Aulhorn-Strasse 7, 72076 Tübingen, Germany.ORCID 0000-0003-2209-2113

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rhodopsin (

Indexed as

AlkaloidsAnimalsAnimals, Genetically ModifiedBenzoquinonesDisease Models, AnimalEndoplasmic ReticulumHumansLactams, MacrocyclicMutationPhotoreceptor Cells, VertebrateProteasome Endopeptidase ComplexProtein FoldingProteolysisRatsRetinaRetinal DegenerationAlkaloidsBenzoquinonesgeldanamycinkifunensineLactams, MacrocyclicProteasome Endopeptidase ComplexRhodopsinocular diseaseocular therapyretinal degenerationretinal organotypic cultureretinitis pigmentosaRHOP23H

Identifiers

PMID34680161
PMCPMC8534135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.