Evidence map›Paper›PMID 34680124›Full record

ArticleBiomolecules2021

Biological Profile of Two

Simona De Vita, Maria Giovanna Chini, Gabriella Saviano, Claudia Finamore, Carmen Festa, Gianluigi Lauro, Simona De Marino, Roberto Russo, Carmen Avagliano, Agostino Casapullo and 3 more

Abstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The protective effect ofFrontiers in nutrition · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Simona De VitaDepartment of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084 Fisciano, Italy.ORCID 0000-0002-8203-3580
Maria Giovanna ChiniDepartment of Biosciences and Territory, University of Molise, Contrada Fonte Lappone, Pesche, 86090 Isernia, Italy.
Gabriella SavianoDepartment of Biosciences and Territory, University of Molise, Contrada Fonte Lappone, Pesche, 86090 Isernia, Italy.
Claudia FinamoreDepartment of Pharmacy, University of Naples, Via Domenico Montesano, 49, 80131 Naples, Italy.
Carmen FestaDepartment of Pharmacy, University of Naples, Via Domenico Montesano, 49, 80131 Naples, Italy.ORCID 0000-0001-8879-4332
Gianluigi LauroDepartment of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084 Fisciano, Italy.
Simona De MarinoDepartment of Pharmacy, University of Naples, Via Domenico Montesano, 49, 80131 Naples, Italy.ORCID 0000-0002-0300-5048
Roberto RussoDepartment of Pharmacy, University of Naples, Via Domenico Montesano, 49, 80131 Naples, Italy.ORCID 0000-0001-5950-1617
Carmen AvaglianoDepartment of Pharmacy, University of Naples, Via Domenico Montesano, 49, 80131 Naples, Italy.
Agostino CasapulloDepartment of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084 Fisciano, Italy.ORCID 0000-0002-2310-9426
Antonio CalignanoDepartment of Pharmacy, University of Naples, Via Domenico Montesano, 49, 80131 Naples, Italy.
Giuseppe BifulcoDepartment of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084 Fisciano, Italy.
Maria IorizziDepartment of Biosciences and Territory, University of Molise, Contrada Fonte Lappone, Pesche, 86090 Isernia, Italy.ORCID 0000-0002-8653-6628

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural products have been the main source of bioactive molecules for centuries. We tested the biological profile of two metabolites extracted from

Indexed as

Computational BiologyMetabolomeAnimalsCell LineCyclooxygenase 2DoxycyclineDrug Evaluation, PreclinicalGentianaIn Vitro TechniquesIridoid GlucosidesIridoidsLigandsMiceMolecular Docking SimulationMolecular Dynamics SimulationProteinsCyclooxygenase 2DoxycyclinegentiopicrosideIridoid GlucosidesIridoidsLigandsloganic acidProteinsbiological profilecancercomputational chemistryinflammationinverse virtual screeningnatural product

Identifiers

PMID34680124
PMCPMC8533323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.