Evidence map›Paper›PMID 34680073›Full record

ArticleBiomolecules2021

Immunoprofiles and DNA Methylation of Inflammatory Marker Genes in Ulcerative Colitis-Associated Colorectal Tumorigenesis.

Satu Mäki-Nevala, Sanjeevi Ukwattage, Erkki-Ville Wirta, Maarit Ahtiainen, Ari Ristimäki, Toni T Seppälä, Anna Lepistö, Jukka-Pekka Mecklin, Päivi Peltomäki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Satu Mäki-NevalaDepartment of Medical and Clinical Genetics, University of Helsinki, FI-00014 Helsinki, Finland.
Sanjeevi UkwattageDepartment of Medical and Clinical Genetics, University of Helsinki, FI-00014 Helsinki, Finland.
Erkki-Ville WirtaDepartment of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, FI-33521 Tampere, Finland.ORCID 0000-0002-2255-6136
Maarit AhtiainenDepartment of Education and Research, Hospital Nova of Central Finland, FI-40620 Jyväskylä, Finland.ORCID 0000-0002-3263-2307
Ari RistimäkiDepartment of Pathology, HUSLAB, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, FI-00029 Helsinki, Finland.ORCID 0000-0002-5373-9234
Toni T SeppäläApplied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, FI-00014 Helsinki, Finland.ORCID 0000-0002-4940-3498
Anna LepistöApplied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, FI-00014 Helsinki, Finland.
Jukka-Pekka MecklinDepartment of Education and Research, Hospital Nova of Central Finland, FI-40620 Jyväskylä, Finland.
Päivi PeltomäkiDepartment of Medical and Clinical Genetics, University of Helsinki, FI-00014 Helsinki, Finland.ORCID 0000-0001-8819-2980
University of Helsinki · FITampere University Hospital · FIUniversity of Jyväskylä · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunological and epigenetic changes are interconnected and contribute to tumorigenesis. We determined the immunoprofiles and promoter methylation of inflammation-related genes for colitis-associated colorectal carcinomas (CA-CRC). The results were compared with Lynch syndrome (LS)-associated colorectal tumors, which are characterized by an active immune environment through inherited mismatch repair defects. CA-CRCs (

Indexed as

BiomarkersCarcinogenesisColitis, UlcerativeColorectal NeoplasmsCpG IslandsDNA MethylationDNA Modification MethylasesDNA Repair EnzymesFemaleGene Expression Regulation, NeoplasticHumansInflammationIntestinal MucosaMaleMiddle AgedMutationBiomarkersDNA Modification MethylasesDNA Repair EnzymesMGMT protein, humanTumor Suppressor Proteinscolon cancerDNA methylationimmune cell scoreinflammation-associated genesLynch syndromeulcerative colitis

Identifiers

PMID34680073
PMCPMC8533626
OpenAlexW3204920848

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.