ReviewBiomolecules2021
Obesity-An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances.
Review in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Deciphering the genetic landscape of obesity: a data-driven approach to identifying plausible causal genes and therapeutic targets.Journal of human genetics · 2023Pooled it
- Pooled it
- Lipid Accumulation Promotes Tumorigenic Behaviour of Colorectal Cancer Cells.Journal of cellular and molecular medicine · 2026Article
- Lean adipocyte oxylipin signaling restrains breast cancer through ferroptosis.Science (New York, N.Y.) · 2026Article
- Review
- The association between obesity and telomere shortening is mediated through total bilirubin.Cardiovascular diabetology. Endocrinology reports · 2026Article
- Forsythoside A Attenuates High-Fat Diet-Induced Obesity by Regulating Thermogenesis and Browning of White Adipose Tissue Through Activation of the AMPK Signaling Pathway.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Physiological interplay among obesity, male fertility, and aryl hydrocarbon receptor in human and mice: A mini review.Open veterinary journal · 2026Review
- 4-Hydroxyphenanthrene exacerbates obesity by altering gut microbiota and bile acid metabolism.Nature communications · 2026Article
- Beyond the conventional risk factors in the management of atherosclerosis in women: a call to action for careful consideration of obesity and inflammation.European heart journal open · 2026Review
- A Systematic Review and Meta-Analysis of the Association Between Obesity and Albuminuria in Asian People.International journal of hypertension · 2026Review
- Review
- Obesity and Depression: A Pathophysiotoxic Relationship.International journal of molecular sciences · 2025Review
- 6,7-Dihydroxy-4-methylcoumarin Suppresses Adipogenesis via AMPK and MAPK Signaling with In Silico Analysis of Adipogenic Proteins.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Association between weight loss and reproductive outcomes among women with overweight or obesity: a cohort study using UK real-world data.Human reproduction (Oxford, England) · 2025Article
- Capsaicinoid Glucoside Attenuates Lipid Accumulation in HepG2 Cells Through TRPV1/AMPK-Dependent Signaling Pathway.Food science & nutrition · 2025Article
- Onboarding obesity management in cardiovascular care: A cardiologist's guide to latest advances.American journal of preventive cardiology · 2025Review
- The impact of dietary interventions on cardiometabolic health.Cardiovascular diabetology · 2025Review
- The glucose transporter GLUT12, a new actor in obesity and cancer.Journal of physiology and biochemistry · 2025Review
- Obesity, white adipose tissue and cancer.The FEBS journal · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity represents a major public health problem with a prevalence increasing at an alarming rate worldwide. Continuous intensive efforts to elucidate the complex pathophysiology and improve clinical management have led to a better understanding of biomolecules like gut hormones, antagonists of orexigenic signals, stimulants of fat utilization, and/or inhibitors of fat absorption. In this article, we will review the pathophysiology and pharmacotherapy of obesity including intersection points to the new generation of antidiabetic drugs. We provide insight into the effectiveness of currently approved anti-obesity drugs and other therapeutic avenues that can be explored.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.