Evidence map›Paper›PMID 34679953›Full record

ArticleAnimals : an open access journal from MDPI2021

Dietary Supplementation of Olive Mill Waste Water Polyphenols in Rabbits: Evaluation of the Potential Effects on Hepatic Apoptosis, Inflammation and Metabolism through RT-qPCR Approach.

Katia Cappelli, Flavia Ferlisi, Samanta Mecocci, Margherita Maranesi, Massimo Trabalza-Marinucci, Massimo Zerani, Alessandro Dal Bosco, Gabriele Acuti

Open access · goldAbstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Katia CappelliDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo, 4, 06126 Perugia, Italy.ORCID 0000-0002-3141-771X
Flavia FerlisiDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo, 4, 06126 Perugia, Italy.
Samanta MecocciDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo, 4, 06126 Perugia, Italy.ORCID 0000-0003-2998-0412
Margherita MaranesiDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo, 4, 06126 Perugia, Italy.ORCID 0000-0002-1727-4118
Massimo Trabalza-MarinucciDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo, 4, 06126 Perugia, Italy.ORCID 0000-0001-9082-0106
Massimo ZeraniDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo, 4, 06126 Perugia, Italy.ORCID 0000-0002-2476-5097
Alessandro Dal BoscoDepartment of Agricultural, Food and Environmental Science, University of Perugia, Borgo XX Giugno, 74, 06100 Perugia, Italy.
Gabriele AcutiDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo, 4, 06126 Perugia, Italy.ORCID 0000-0003-4279-8164
University of Perugia · IT

Funding

This research was funded by Regione Umbria - Progetti Complessi di Ricerca e Sviluppo POR FERS 2014-2020 ("Poli4Liquid_animalfeed"). POR FERS 2014-2020
6 · The paper itself

Abstract

Agro-industrial processing for the production of food or non-food products generates a wide range of by-products and residues rich in bioactive compounds including polyphenols. The concentration of these by-products is sometimes higher than in the original raw material as in the case of olive mill waste water (OMWW), one of the main by-products of olive oil extraction. Polyphenols are secondary plant metabolites that regulate the expression of specific inflammatory genes, transcriptional factors and pro/anti-apoptotic molecules, thus modulating the signaling pathways essential for cell health and homeostasis. The liver plays a key role in regulating homeostasis by responding to dietary changes in order to maintain nutritional and physiological states. In this study a nutrigenomic approach was adopted, which focuses on the effects of diet-health-gene interactions and the modulation of cellular processes, in order to evaluate the expression of the genes (

Indexed as

gene expressionliverolive mill waste waterspolyphenolsrabbitRT-qPCR

Identifiers

PMID34679953
PMCPMC8532769
OpenAlexW3206581395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.