ArticleAnimals : an open access journal from MDPI2021
Species-Level Gut Microbiota Analysis after Antibiotic-Induced Dysbiosis in Horses.
Article in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- A Comprehensive Review of the Equine Gut Microbiome in Health and Disease.Veterinary sciences · 2026Review
- Long-Read Sequencing for Species-Level Resolution of the Equine Gut Microbiota Reveals the Need for Improved Databases.Animals : an open access journal from MDPI · 2026Article
- Surfactin from Bacillus subtilis 1-4 disrupts the cell membrane of zoonotic Staphylococcus intermedius in vitro and maintains gut microbiota community in urban pigeons.Gut pathogens · 2026Article
- Gut microbiota variation in captive tortoises is associated with host species, trophic category, and growth rate.Frontiers in microbiology · 2026Article
- The Gut Microbial Adaptation of Wild Goitered Gazelles Under Antibiotic Pressure in the Qaidam Basin.Microorganisms · 2025Article
- Microbiome analysis reveals dynamic changes of gut microbiota in Guizhou horse and Dutch Warmblood horses.Frontiers in microbiology · 2025Article
- Current Understanding of Equine Gut Dysbiosis and Microbiota Manipulation Techniques: Comparison with Current Knowledge in Other Species.Animals : an open access journal from MDPI · 2024Review
- The Microbiota and Equine Asthma: An Integrative View of the Gut-Lung Axis.Animals : an open access journal from MDPI · 2024Review
- Effects of concentrated fecal microbiota transplant on the equine fecal microbiota after antibiotic-induced dysbiosis.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2023Article
- Effect of dietary iron supplementation on the equine fecal microbiome.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2023Article
- Article
- Effects of Intravenous Antimicrobial Drugs on the Equine Fecal Microbiome.Animals : an open access journal from MDPI · 2022Article
- The Immune Mechanisms of Severe Equine Asthma-Current Understanding and What Is Missing.Animals : an open access journal from MDPI · 2022Review
- Metagenomic investigation of the equine faecal microbiome reveals extensive taxonomic diversity.PeerJ · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
All current studies have used Illumina short-read sequencing to characterize the equine intestinal microbiota. Long-read sequencing can classify bacteria at the species level. The objectives of this study were to characterize the gut microbiota of horses at the species level before and after trimethoprim sulfadiazine (TMS) administration and to compare results with Illumina sequencing. Nine horses received TMS (30 mg/kg) orally for 5 days twice a day to induce dysbiosis. Illumina sequencing of the V4 region or full-length PacBio sequencing of the 16S rRNA gene was performed in fecal samples collected before and after antibiotic administration. The relative abundance and alpha diversity were compared between the two technologies. PacBio failed to classify the equine intestinal microbiota at the species level but confirmed Bacteroidetes as the most abundant bacteria in the feces of the studied horses, followed by Firmicutes and Fibrobacteres. An unknown species of the Bacteroidales order was highly abundant (13%) and deserves further investigation. In conclusion, PacBio was not suitable to classify the equine microbiota species but detected greater richness and less unclassified bacteria. Further efforts in improving current databanks to be used in equine studies are necessary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.