ArticleAnimals : an open access journal from MDPI2021
Oocyte Morphometric Assessment and Gene Expression Profiling of Oocytes and Cumulus Cells as Biomarkers of Oocyte Competence in Sheep.
Article in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Oocyte-cumulus cell interaction: a key factor in early embryo development.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Germinal vesicle oocytes' rescue: a worthless treatment or a patient-centred approach? Eight years of clinical experience in poor prognosis patients.Human reproduction (Oxford, England) · 2026Article
- Protective effect of dietary L-carnitine supplementation on follicular development in the ovary of ewes with subclinical pregnancy toxemia.Archives animal breeding · 2026Article
- Artificial intelligence outperforms humans in morphology-based oocyte selection in cattle.Scientific reports · 2025Article
- Comparative Assessment of Morphometry, Morphology, and Maturation Capacity of Vitrified Cattle Oocytes in Different Media.Veterinary sciences · 2025Article
- The effect of single versus group culture on cumulus-oocyte complexes from early antral follicles.Journal of assisted reproduction and genetics · 2025Article
- Single-Cell Transcriptome Analysis Reveals Development-Specific Networks at Distinct Synchronized Antral Follicle Sizes in Sheep Oocytes.International journal of molecular sciences · 2024Article
- The impact of epigenetic landscape on ovarian cells in infertile older women undergoing IVF procedures.Clinical epigenetics · 2023Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Oocyte quality is crucial for subsequent embryo development and so it is a major challenge in assisted reproductive technologies. The aim of the present work was to evaluate the morphometric parameters of oocytes (experiment 1) and the relative gene expression of oocytes and cumulus cells (CCs) (experiment 2) as biomarkers of oocyte quality after individually culturing them (one oocyte or embryo/drop). In experiment 1, individually matured oocytes were measured and classified into small, intermediate, and large oocytes after a cluster analysis, based on total diameter (with zona pellucida, ZP), oocyte diameter (without ZP), and ZP thickness. These oocytes were individually fertilized in vitro and cultured. The embryo development was evaluated up to the blastocyst stage. According to the total diameter, oocyte diameter, and ZP thickness, the blastocyst rate decreased in the small oocytes group (3.1 ± 3.1, 14.1 ± 9.4, and 26.7 ± 3.9, respectively) compared to the intermediate (29.4 ± 5.2, 30.5 ± 10.1, and 28.6 ± 9.6, respectively) and large oocytes groups (54.2 ± 13.5, 44.4 ± 3.9, and 67.6 ± 12.4, respectively). In addition, the probability of reaching the blastocyst stage was positively related to the total diameter (
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