Evidence map›Paper›PMID 34679755›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Salvianolic Acid C Protects against Cisplatin-Induced Acute Kidney Injury through Attenuation of Inflammation, Oxidative Stress and Apoptotic Effects and Activation of the CaMKK-AMPK-Sirt1-Associated Signaling Pathway in Mouse Models.

Liang-Hsuan Chien, Chien-Ta Wu, Jeng-Shyan Deng, Wen-Ping Jiang, Wen-Chin Huang, Guan-Jhong Huang

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Cisplatin-Induced Nephrotoxicity Attenuation byInternational journal of molecular sciences · 2026
    Article
  5. Review
  6. The Brown Strain ofInternational journal of molecular sciences · 2026
    Article
  7. Article
  8. Antioxidants (Basel, Switzerland) · 2026
    Article
  9. Article
  10. Review
  11. Salvianolic Acids and Their Pharmacological Promise in Kidney Diseases: A Narrative Review.International journal of nephrology and renovascular disease · 2026
    Review
  12. Review
  13. Review
  14. Multi-Target Protective Effects ofInternational journal of molecular sciences · 2025
    Article
  15. Article
  16. Article
  17. Review
  18. Renoprotective Effects of Brown-StrainInternational journal of molecular sciences · 2024
    Article
  19. Article
  20. Dietary ProbioticNutrients · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Liang-Hsuan ChienDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.ORCID 0000-0002-8737-3410
Chien-Ta WuFaculty of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Jeng-Shyan DengDepartment of Health and Nutrition Biotechnology, Asia University, Taichung 413, Taiwan.
Wen-Ping JiangDepartment of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan.
Wen-Chin HuangGraduate Institute of Biomedical Sciences, School of Medicine, China Medical University, Taichung 404, Taiwan.ORCID 0000-0003-2342-9099
Guan-Jhong HuangDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.ORCID 0000-0002-9822-3485
Asia University · TWChina Medical University · TWChia Nan University of Pharmacy and Science · TWKaohsiung Medical University · TW

Funding

National Science Council 105-2320-B-039-046-
6 · The paper itself

Abstract

Acute kidney injury (AKI) is a sudden reduction in kidney activity and has a high mortality rate. Salvianolic acid C (SAC), one of the main polyphenolic components of

Indexed as

acute kidney injuryanti-inflammationapoptosisCaMKK–AMPK–Sirt1 pathwaycisplatinoxidative stresssalvianolic acid C

Identifiers

PMID34679755
PMCPMC8533075
OpenAlexW3207019262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.