Evidence map›Paper›PMID 34679701›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Antihyperlipidemic and Antioxidant Capacities, Nutritional Analysis and UHPLC-PDA-MS Characterization of Cocona Fruits (

Gabriel Vargas-Arana, Claudia Merino-Zegarra, Marcos Riquelme-Penaherrera, Luis Nonato-Ramirez, Henry Delgado-Wong, Mariano Walter Pertino, Claudio Parra, Mario J Simirgiotis

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Berries fromPlants (Basel, Switzerland) · 2025
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  5. Advances in Natural Antioxidants for Food Improvement.Antioxidants (Basel, Switzerland) · 2022
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  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Gabriel Vargas-AranaLaboratorio de Química de Productos Naturales, Instituto de Investigaciones de la Amazonía Peruana, Av. Abelardo Quiñones km 2.5, Iquitos 16001, Peru.ORCID 0000-0002-0808-4283
Claudia Merino-ZegarraLaboratorio de Química de Productos Naturales, Instituto de Investigaciones de la Amazonía Peruana, Av. Abelardo Quiñones km 2.5, Iquitos 16001, Peru.
Marcos Riquelme-PenaherreraFacultad de Farmacia y Bioquímica, Universidad Nacional de la Amazonía Peruana, Iquitos 16001, Peru.
Luis Nonato-RamirezFacultad de Farmacia y Bioquímica, Universidad Nacional de la Amazonía Peruana, Iquitos 16001, Peru.ORCID 0000-0003-2704-1622
Henry Delgado-WongFacultad de Farmacia y Bioquímica, Universidad Nacional de la Amazonía Peruana, Iquitos 16001, Peru.
Mariano Walter PertinoLaboratorio de Química de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca 3460000, Chile.ORCID 0000-0002-0203-4891
Claudio ParraLaboratorio de Química Orgánica y Productos Naturales, Facultad de Ciencias Agronómicas, Universidad de Tarapacá, Av. General Velásquez 1775, Arica 1000000, Chile.ORCID 0000-0001-7356-2782
Mario J SimirgiotisInstituto de Farmacia, Facultad de Ciencias, Universidad Austral de Chile, Valdivia 509000, Chile.ORCID 0000-0003-4552-3123
Universidad Nacional de la Amazonía Peruana · PEInstituto de Investigaciones de la Amazonía Peruana · PEAustral University of Chile · CLUniversity of Talca · CLUniversity of Tarapacá · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cocona fruits are a popular food and medicinal fruit used mainly in the Amazon and several countries of South America for the preparation of several food products such as drinks, jams and milk shakes. In this study five ecotypes of cocona native to Peru have been studied regarding their nutritional and antioxidants values plus antihyperlipidemic activities. Seventy bioactive compounds have been detected in Peruvian cocona ecotypes including several phenolic acids, aminoacids and flavonoids; of those six were spermidines, (peaks 1, 2, 25, 26, 38 and 39), thirteen were aminoacids, (peaks 3-9, 11-13, 16, 17, 22-24), eighteen flavonoids (peaks 28, 30-32 45,46, 48-53 56, 57, 61 and 64-66), twelve were phenolics (peaks 19, 21, 27, 29, 34, 35, 36, 42, 43, 44, 54, and 59), two carotenoids, (peak 62 and 63), eight were lipid derivatives (peaks 37, 55, 58, 60 and 67-70), one sugar (peak 47), four terpenes (peaks 33, 40, 41 and 47), two amides, (peaks 10 and 18), one aldehyde, (peak 15), and three saturated organic acids, (peaks 4, 5 and 20). Hypercholesterolemic rats administered with pulp of the ecotypes CTR and SRN9 showed the lowest cholesterol and triglyceride levels after treatment (126.74 ± 6.63; 102.11 ± 9.47; 58.16 ± 6.64; 61.05 ± 4.00 mg/dL, for cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein respectively, for the group treated with SRN9 pulp, and 130.09 ± 8.55; 108.51 ± 10.04; 57.30 ± 5.72; and 65.41 ± 7.68 mg/dL, for cholesterol, triglycerides, HDL and LDL lipoproteins respectively for the group treated with CTR pulp). The ecotypes proved to be good sources of natural antioxidants and their consumption represent an alternative for the prevention of atherosclerosis.

Indexed as

antihyperlipidemicantioxidant activitynutritional valuesphenolicsSolanaceaeUHPLC-PDA-ESI-OT-MS

Identifiers

PMID34679701
PMCPMC8533405
OpenAlexW3202977530

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.