Evidence map›Paper›PMID 34679664›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Dimeric Histidine as a Novel Free Radical Scavenger Alleviates Non-Alcoholic Liver Injury.

Zizhen Zhao, Chen Fu, Yuping Zhang, Ailing Fu

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zizhen ZhaoSchool of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Chen FuSchool of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.ORCID 0000-0002-9924-0797
Yuping ZhangSchool of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Ailing FuSchool of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Southwest University · CN

Funding

National Natural Science Foundation of China 82073830
6 · The paper itself

Abstract

Non-alcoholic liver injury (NLI) is a common disease worldwide. Since free radical damage in the liver is a crucial initiator leading to diseases, scavenging excess free radicals has become an essential therapeutic strategy. To enhance the antioxidant capacity of histidine, we synthesized a protonated dimeric histidine, H-bihistidine, and investigated its anti-free radical potential in several free-radical-induced NLI. Results showed that H-bihistidine could strongly scavenge free radicals caused by H

Indexed as

fatty liverH-bihistidineliver fibrosisnonalcoholic liver injuryoxidation injury

Identifiers

PMID34679664
PMCPMC8532998
OpenAlexW3204117354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.