Evidence map›Paper›PMID 34679572›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Longitudinal Assessment of Tau-Associated Pathology by

Ines Moreno-Gonzalez, George A Edwards, Omar Hasan, Nazaret Gamez, Jonathan E Schulz, Juan Jose Fernandez-Valenzuela, Antonia Gutierrez, Claudio Soto, Paul E Schulz

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Ines Moreno-GonzalezDepartment of Neurology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.ORCID 0000-0003-3875-0889
George A EdwardsDepartment of Neurology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Omar HasanDepartment of Neurology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.ORCID 0000-0002-3451-3299
Nazaret GamezDepartment of Neurology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.ORCID 0000-0001-6847-7735
Jonathan E SchulzDepartment of Neurology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Juan Jose Fernandez-ValenzuelaDepartment of Cell Biology, Instituto de Investigacion Biomedica de Malaga-IBIMA, Faculty of Sicences, University of Malaga, 29010 Malaga, Spain.
Antonia GutierrezDepartment of Cell Biology, Instituto de Investigacion Biomedica de Malaga-IBIMA, Faculty of Sicences, University of Malaga, 29010 Malaga, Spain.ORCID 0000-0002-6264-6152
Claudio SotoDepartment of Neurology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Paul E SchulzDepartment of Neurology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.ORCID 0000-0003-0676-002X
The University of Texas Health Science Center at Houston · USBiomedical Research Networking Center on Neurodegenerative Diseases · ESInstituto de Investigación Biomédica de Málaga · ES

Funding

Alzheimer's Association NIRG-394284Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía P18-RT-2233Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía UMA18-FEDERJA-211Instituto de Salud Carlos III PI18/01557Ministerio de Ciencia e Innovación PID2019-107090RA-100Ministerio de Ciencia e Innovación RYC-2017-21879National Alliance for Research on Schizophrenia and Depression 27565U.S. Department of Defense AZ160106
6 · The paper itself

Abstract

Several common and debilitating neurodegenerative disorders are characterized by the intracellular accumulation of neurofibrillary tangles (NFTs), which are composed of hyperphosphorylated tau protein. In Alzheimer's disease (AD), NFTs are accompanied by extracellular amyloid-beta (Aβ), but primary tauopathy disorders are marked by the accumulation of tau protein alone, including forms of frontotemporal dementia (FTD), corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP), among others.

Indexed as

Alzheimer’s diseasebiomarkercognitive impairmentdementiahistological assessmentPET imagingTautauopathyTHK5351tracer

Identifiers

PMID34679572
PMCPMC8535097
OpenAlexW3205706912

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.