Evidence map›Paper›PMID 34679508›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Automatic Recognition of Colon and Esophagogastric Cancer with Machine Learning and Hyperspectral Imaging.

Toby Collins, Marianne Maktabi, Manuel Barberio, Valentin Bencteux, Boris Jansen-Winkeln, Claire Chalopin, Jacques Marescaux, Alexandre Hostettler, Michele Diana, Ines Gockel

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Clinical applications of hyperspectral imaging in gastroenterology and hepatology: A systematic review.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Pooled it
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  4. Article
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  7. Classification of esophageal cancer by using hyperspectral data.International journal of computer assisted radiology and surgery · 2026
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  8. Review
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  12. Precision Imaging for Early Detection of Esophageal Cancer.Bioengineering (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Toby CollinsInstitute for Research against Digestive Cancer (IRCAD), 67091 Strasbourg, France.
Marianne MaktabiInnovation Center Computer-Assisted Surgery (ICCAS), University of Leipzig, 04103 Leipzig, Germany.ORCID 0000-0001-6954-4530
Manuel BarberioInstitute for Research against Digestive Cancer (IRCAD), 67091 Strasbourg, France.ORCID 0000-0002-8241-6442
Valentin BencteuxICUBE Laboratory, Photonics Instrumentation for Health, University of Strasbourg, 67400 Strasbourg, France.
Boris Jansen-WinkelnDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, 04103 Leipzig, Germany.
Claire ChalopinInnovation Center Computer-Assisted Surgery (ICCAS), University of Leipzig, 04103 Leipzig, Germany.ORCID 0000-0001-9309-7531
Jacques MarescauxInstitute for Research against Digestive Cancer (IRCAD), 67091 Strasbourg, France.ORCID 0000-0002-1400-6230
Alexandre HostettlerInstitute for Research against Digestive Cancer (IRCAD), 67091 Strasbourg, France.ORCID 0000-0001-8269-6766
Michele DianaInstitute for Research against Digestive Cancer (IRCAD), 67091 Strasbourg, France.ORCID 0000-0002-1390-8486
Ines GockelDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, 04103 Leipzig, Germany.ORCID 0000-0001-7423-713X
Institut de Recherche contre les Cancers de l’Appareil Digestif · FRLeipzig University · DEUniversity Hospital Leipzig · DEInserm · FRLaboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie · FR

Funding

German Federal Ministry of Education and Research 13GW0248B
6 · The paper itself

Abstract

There are approximately 1.8 million diagnoses of colorectal cancer, 1 million diagnoses of stomach cancer, and 0.6 million diagnoses of esophageal cancer each year globally. An automatic computer-assisted diagnostic (CAD) tool to rapidly detect colorectal and esophagogastric cancer tissue in optical images would be hugely valuable to a surgeon during an intervention. Based on a colon dataset with 12 patients and an esophagogastric dataset of 10 patients, several state-of-the-art machine learning methods have been trained to detect cancer tissue using hyperspectral imaging (HSI), including Support Vector Machines (SVM) with radial basis function kernels, Multi-Layer Perceptrons (MLP) and 3D Convolutional Neural Networks (3DCNN). A leave-one-patient-out cross-validation (LOPOCV) with and without combining these sets was performed. The ROC-AUC score of the 3DCNN was slightly higher than the MLP and SVM with a difference of 0.04 AUC. The best performance was achieved with the 3DCNN for colon cancer and esophagogastric cancer detection with a high ROC-AUC of 0.93. The 3DCNN also achieved the best DICE scores of 0.49 and 0.41 on the colon and esophagogastric datasets, respectively. These scores were significantly improved using a patient-specific decision threshold to 0.58 and 0.51, respectively. This indicates that, in practical use, an HSI-based CAD system using an interactive decision threshold is likely to be valuable. Experiments were also performed to measure the benefits of combining the colorectal and esophagogastric datasets (22 patients), and this yielded significantly better results with the MLP and SVM models.

Indexed as

cancercomputer-assisted diagnosisconvolutional neural networkshyperspectral imagingimage-guided surgerymachine learning

Identifiers

PMID34679508
PMCPMC8535008
OpenAlexW3204179093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.