ArticleDiagnostics (Basel, Switzerland)2021
Evaluation of the New Beckmann Coulter Analyzer DxH 900 Compared to Sysmex XN20: Analytical Performance and Flagging Efficiency.
Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Real-World Evaluation of the Sysmex XN-9100 WDF-WPC Workflow: Diagnostic Performance, False-Negative Burden, and Potential Optimization of Smear Review Workload.Diagnostics (Basel, Switzerland) · 2026Article
- Evaluation of machine learning pipeline for blood culture outcome prediction on prospectively collected emergency department data.Journal of medical microbiology · 2026Article
- Neonatal leucocyte cell population data: reference intervals and relevance for detecting sepsis and necrotizing enterocolitis.Pediatric research · 2026Article
- Clinical validation of the Hilab lens for AI supported point of care CBC testing in pediatric oncology.Communications medicine · 2025Article
- Integrating Cell Population Data With Hematology Analyzer Messages for Improved Detection of Immature White Blood Cells and Laboratory Efficiency.Journal of clinical laboratory analysis · 2025Article
- The dilution evaluation as a corrective measure for interference in the white blood cell scattergram in Beckman Coulter DxH 900.Journal of clinical laboratory analysis · 2024Article
- Performance evaluation of the new Sysmex XR-Series haematology analyser.Practical laboratory medicine · 2024Article
- A comparative study of blood cell count in four automated hematology analyzers: An evaluation of the impact of preanalytical factors.PloS one · 2024Article
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Authors and funding
5 authors.
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Abstract
Efficiency and accuracy in automated hematology analyzers are very important for clinical laboratories. The purpose was to evaluate the flags and results reported by the newest Beckman Coulter analyzer DxH 900 compared to the Sysmex XN20 system. Samples were analyzed on the XN20 (Sysmex, Kobe, Japan) and on the Beckman Coulter DxH 900 (Beckman Coulter, Miami, Florida, USA). Slide reviews were performed microscopically. Morphologic criteria were used to identify abnormal cells as recommended by International Consensus Group for Hematology (ICSH): blasts, immature granulocytes (IG%), abnormal lymphocytes (ALs) and plasma cells. Results: there was a strong correlation between the analyzers in almost all clinical parameters tested. Both DxH 900 and XN20 showed an excellent degree of association for the leukocyte differential compared to the reference method (manual microscopy). When it comes to IG%, XN20 showed a positive bias for higher results. Related to platelets, there are no differences between the two methods for PLT count. For mean platelet volume (MPV), DxH 900 provided 100% results of the samples analyzed while XN20 while in the XN20 analyzer, 16% of the results were missing. From our results we came to the conclusion that both analyzers, DxH 900 and XN20 were clinically accurate and efficient. Abnormal Lymphocyte detection highlighted the differences between the two technologies as only minimal agreement was obtained. DxH 900 demonstrated higher sensitivity in detecting IG with good correlation with microscopic review. The DxH 900 for platelet clumps identification provides an excellent flag (PLT Clumps) with the highest sensitivity observed in our evaluation.
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